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Lorazepam by Rectum

Your child needs to take the medicine called lorazepam​ (say: lor-A-ze-pam). This information sheet explains what lorazepam does, how to give it, and what side effects, or problems your child may have when he or she takes this medicine.

What is lorazepam?

Lorazepam is used as a sedative and as a muscle relaxant. It is also used in the treatment of seizures.

How should I give my child lorazepam?

  • Give this medicine exactly as directed.
  • Be sure you have enough of this medication on hand at all times
  • Keep this medication in the refrigerator and protected from light

What are the possible side effects of lorazepam?

  • This medicine may make your child dizzy, drowsy, or less alert than normal.

When should I contact my doctor?

Contact your doctor immediately if your child has:

  • confusion
  • shortness of breath
  • severe drowsiness
  • trouble breathing
  • shakiness
  • slurred speech
  • severe weakness

Instructions for administration of lorazepam:

  1. Open the vial by pushing against the metal top.
  2. Carefully measure out the exact dose as indicated on the marked syringe provided by your pharmacist, or measure             mL.
  3. Draw up into the same syringe an equal amount of tap water.
  4. Mix contents thoroughly by gently inverting the syringe a few times.
  5. Lubricate the outside of the syringe barrel with K-Y Jelly or Muko.
  6. Insert the syringe into rectum (3.5 to 5 cm or 1 ½ to 2 inches) just like a thermometer.
  7. Inject lorazepam by pressing down slowly on the plunger while squeezing buttocks together. Remove the syringe and continue to squeeze the buttocks for a few minutes.
  8. If the seizure does not stop in 5 minutes, bring your child to a hospital emergency department, unless otherwise instructed by your doctor.

Keep lorazepam out of your child’s sight and reach and locked up in a safe place. If your child takes too much lorazepam, call the Ontario Poison Centre at one of these numbers. These calls are free.

  • Call 416-813-5900 if you live in Toronto.
  • Call 1-800-268-9017 if you live somewhere else in Ontario.
  • If you live outside of Ontario, call your local Poison Information Centre.

Disclaimer: The information in this Family Med-aid is accurate at the time of printing. It provides a summary of information about lorazepam and does not contain all possible information about this medicine. Not all side effects are listed. If you have any questions or want more information about lorazepam, speak to your health care provider.

Jennifer Drynan-Arsenault, BSc, RPh, ACPR