Treatment of optic and hypothalamic gliomasTTreatment of optic and hypothalamic gliomasTreatment of optic and hypothalamic gliomasEnglishNeurology;OncologyChild (0-12 years);Teen (13-18 years)BrainNervous systemDrug treatment;Non-drug treatmentAdult (19+)NA2009-07-10T04:00:00ZEric Bouffet, MD, FRCPCUte Bartels, MD11.000000000000044.0000000000000240.000000000000Flat ContentHealth A-Z<p>An in-depth look at treatment possibilities for a child with a hypothalamic or optic glioma.<br></p><p>The goal of treatment is to save the child’s sight and hormone functions. Children with a condition called <a href="/Article?contentid=864&language=English">neurofibromatosis​</a> (NF-1) tend to have more slow-growing tumours. Tumours are more aggressive in children under the age of one.</p><h2>Key points</h2> <ul><li>Observation will be recommended if the tumour is not growing.</li> <li>Surgery is difficult because of the tumour's location but may be recommended if the symptoms get worse, the tumour is easily accessible, or to place a shunt for hydrocephalus.</li> <li>Chemotherapy and radiation are most commonly used as treatment.</li> <li>The outcome of treatment is better if the tumour does not involve the optic chiasm or grow along the visual pathway.</li></ul>
Traitement des gliomes optiques et hypothalamiquesTTraitement des gliomes optiques et hypothalamiquesTreatment of optic and hypothalamic gliomasFrenchNeurology;OncologyChild (0-12 years);Teen (13-18 years)BrainNervous systemDrug treatment;Non-drug treatmentAdult (19+)NA2009-07-10T04:00:00ZEric Bouffet, MD, FRCPCUte Bartels, MD11.000000000000044.0000000000000240.000000000000Flat ContentHealth A-Z<p>Examen approfondi des possibilités de traitement pour un enfant atteint d'un gliome optique ou hypothalamique.<br></p><p>Le but du traitement consiste à sauver la vue et les fonctions hormonales de l’enfant. Les enfants qui sont atteints d'un trouble médical nommé <a href="/article?contentid=864&language=French">neurofibromatose de type 1 (NF1)</a> ont tendance à avoir des tumeurs qui se développent lentement. Les tumeurs sont plus vigoureuses chez les enfants âgés de moins d’un an.</p><h2>À retenir</h2> <ul><li>On recommandera l’observation dans les cas où la tumeur ne grandit pas.</li> <li>L’intervention chirurgicale est difficile, car la tumeur se trouve dans une région délicate, mais elle pourrait être recommandée si les symptômes s’aggravent, si la tumeur est facilement accessible ou pour placer un shunt dans le cas d’une hydrocéphalie.</li> <li>La chimiothérapie et la radiothérapie sont les traitements les plus fréquents.</li> <li>Le résultat est meilleur si la tumeur ne touche pas le chiasma des nerfs optiques ou si elle ne se développe pas le long des voies optiques.</li></ul>

 

 

Treatment of optic and hypothalamic gliomas1358.00000000000Treatment of optic and hypothalamic gliomasTreatment of optic and hypothalamic gliomasTEnglishNeurology;OncologyChild (0-12 years);Teen (13-18 years)BrainNervous systemDrug treatment;Non-drug treatmentAdult (19+)NA2009-07-10T04:00:00ZEric Bouffet, MD, FRCPCUte Bartels, MD11.000000000000044.0000000000000240.000000000000Flat ContentHealth A-Z<p>An in-depth look at treatment possibilities for a child with a hypothalamic or optic glioma.<br></p><p>The goal of treatment is to save the child’s sight and hormone functions. Children with a condition called <a href="/Article?contentid=864&language=English">neurofibromatosis​</a> (NF-1) tend to have more slow-growing tumours. Tumours are more aggressive in children under the age of one.</p><h2>Key points</h2> <ul><li>Observation will be recommended if the tumour is not growing.</li> <li>Surgery is difficult because of the tumour's location but may be recommended if the symptoms get worse, the tumour is easily accessible, or to place a shunt for hydrocephalus.</li> <li>Chemotherapy and radiation are most commonly used as treatment.</li> <li>The outcome of treatment is better if the tumour does not involve the optic chiasm or grow along the visual pathway.</li></ul><h2>How are optic or hypothalamic gliomas treated?</h2><p>Observation may be recommended in cases if the tumour is not growing, which occurs typically if a child has NF-1. The tumour will be checked regularly by magnetic resonance imaging (MRI). Treatment will be considered in a number of cases, such as if: </p><ul><li> the tumour is large</li><li> the tumour grows in size</li><li> there is a threat to the child’s vision </li><li> new symptoms develop </li><li> existing symptoms get worse</li></ul><p>There is no test to predict the behaviour of an optic or hypothalamic glioma. For this reason, treatment may vary from one doctor to another depending on the doctor's experience and personal opinion. </p><p>Surgery is difficult because the tumour is in a sensitive area. However, it may be recommended if symptoms get worse, if the tumour is easily accessible, or to place a shunt if the child develops hydrocephalus. The shunt helps relieve the pressure caused by the build-up of cerebrospinal fluid (CSF) that leads to hydrocephalus. </p><p>Radiation therapy, which is the use of high-energy X-rays, gamma rays, or electrons to destroy tumour cells, has been the treatment of choice in the past. </p><p>Chemotherapy, the use of drugs to kill tumour cells, has shown some success in treatment. Chemotherapy treatment lasts one to 1½ years. It is given on an outpatient basis, and it is generally not intensive. The side effects are mild to moderate, and life can go on relatively normally. The most widely used combination of chemotherapy drugs is <a href="/Article?contentid=262&language=English">vincristine</a> and <a href="/article?contentid=91&language=English">carboplatin</a>. </p><h2>What is the outcome for an optic or hypothalamic glioma?</h2><p>The outcome for a child with an optic or hypothalamic glioma depends on many factors. These factors include the child’s age, the location of the tumour, and the size. In most cases, because the tumour grows slowly, the child’s condition will remain stable for long periods. In some cases, it has been reported that the tumour disappeared on its own (regressed). The outcome is better if the tumour does not involve the optic chiasm or grow along the visual pathway. Children with NF-1 also have a better outcome. </p><p>For more information please see:</p><ul><li> <a href="/article?contentid=1310&language=English">Optic and Hypothalamic Gliomas </a></li><li> <a href="/Article?contentid=1324&language=English">Diagnosis of Optic and Hypothalamic Gliomas</a> </li></ul>Treatment of optic and hypothalamic gliomas

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