Treatment of high grade gliomasTTreatment of high grade gliomasTreatment of high grade gliomasEnglishNeurology;OncologyChild (0-12 years);Teen (13-18 years)Brain;SpineNervous systemDrug treatment;Non-drug treatmentAdult (19+)NA2009-07-10T04:00:00ZEric Bouffet, MD, FRCPCUte Bartels, MD000Flat ContentHealth A-Z<p>Information about the treatment of a type of brain tumour called high grade glioma.</p><p>Supratentorial high grade gliomas are treated with surgery. The goal of surgery is always to remove the entire tumour or as much of the tumour as possible. The amount of tumour that can be removed depends highly on the location of the tumour. Tumours located in the cerebral cortex are easier to remove completely than tumours located in other areas of the brain. The more tumour that can be removed, the better the outcome for the child. In children over the age of three years, surgery is combined with radiation and chemotherapy.</p><h2>Key points</h2> <ul><li>Surgery is the main form of treatment and is combined with radiation and chemotherapy in children older than three years old.</li> <li>Chemotherapy has not yet been shown to have a proven benefit in the treatment of this tumour type.</li> <li>Survival rates are higher in children youngerr than three years old than in those older than three.</li></ul>
Traitement des gliomes de haut gradeTTraitement des gliomes de haut gradeTreatment of high grade gliomasFrenchNeurology;OncologyChild (0-12 years);Teen (13-18 years)Brain;SpineNervous systemDrug treatment;Non-drug treatmentAdult (19+)NA2009-07-10T04:00:00ZEric Bouffet, MD, FRCPCUte Bartels, MD000Flat ContentHealth A-Z<p>Renseignements sur le traitement d’un type de tumeur cérébrale qui porte le nom de gliome de haut grade.</p><p>On traite les gliomes de haut grade sustentoriels par la chirurgie. Le but de la chirurgie est toujours de retirer toute la tumeur ou le plus possible. La quantité de tumeur qui peut être retirée dépend grandement de son emplacement. Les tumeurs situées dans le cortex cérébral sont plus faciles à retirer complètement que celles situées dans d’autres régions de l’encéphale. Plus on peut retirer une grande partie de la tumeur, meilleur sera le résultat pour votre enfant. Chez les enfants âgés de plus de trois ans, la chirurgie est combinée à la radiothérapie et la chimiothérapie.</p><h2>À retenir</h2> <ul><li>L’intervention chirurgicale est la principale forme de traitement et elle est combinée avec de la radiothérapie et de la chimiothérapie chez les enfants âgés de plus de trois ans.</li> <li>L’avantage procuré par la chimiothérapie dans le traitement de ce type de tumeur n’a pas encore été démontré.</li> <li>Chez les enfants âgés de moins de trois ans, les taux de survie sont supérieurs à ceux des enfants âgés de plus de trois ans.</li></ul>

 

 

Treatment of high grade gliomas1362.00000000000Treatment of high grade gliomasTreatment of high grade gliomasTEnglishNeurology;OncologyChild (0-12 years);Teen (13-18 years)Brain;SpineNervous systemDrug treatment;Non-drug treatmentAdult (19+)NA2009-07-10T04:00:00ZEric Bouffet, MD, FRCPCUte Bartels, MD000Flat ContentHealth A-Z<p>Information about the treatment of a type of brain tumour called high grade glioma.</p><p>Supratentorial high grade gliomas are treated with surgery. The goal of surgery is always to remove the entire tumour or as much of the tumour as possible. The amount of tumour that can be removed depends highly on the location of the tumour. Tumours located in the cerebral cortex are easier to remove completely than tumours located in other areas of the brain. The more tumour that can be removed, the better the outcome for the child. In children over the age of three years, surgery is combined with radiation and chemotherapy.</p><h2>Key points</h2> <ul><li>Surgery is the main form of treatment and is combined with radiation and chemotherapy in children older than three years old.</li> <li>Chemotherapy has not yet been shown to have a proven benefit in the treatment of this tumour type.</li> <li>Survival rates are higher in children youngerr than three years old than in those older than three.</li></ul><h2>How are high grade gliomas treated?</h2><h3>Supratentorial high grade gliomas</h3><p>Radiation is a mainstay of treatment for children over three years of age. In all studies published in the past 25 years, radiation has been used. New advances have allowed doctors to restrict the effects of radiation to the involved area while sparing normal surrounding brain tissue. Radiation is sometimes combined with a type of drug called radiosensitizers.</p><p>The role of chemotherapy in the treatment of high grade gliomas is still unclear. Chemotherapy has not yet been shown to have a proven benefit in the treatment of this tumour type. However, some older studies have suggested a benefit and therefore many physicians will consider giving chemotherapy during and/or after radiation. If chemotherapy is given, it is usually provided as part of a clinical trial or study. In general practice, some children may be carefully considered and chosen for the use of chemotherapy in the treatment of this type of tumour. Sometimes high-dose chemotherapy is given in the treatment of high grade glioma.</p><p>In general though, two-year survival rates for children with supratentorial high grade gliomas are poor, ranging from 10% to 30%.</p><p>In children under the age of three years, survival rates are higher, even in the absence of radiation. The reason for such a difference is still unclear and might be related to differences in the biology of high grade glioma in infants.</p><h3>Brainstem gliomas<br></h3><p>For information about the treatment of this type of tumour, see the page entitled “<a href="/article?contentid=1360&language=English">Treatment of Diffuse Pontine Gliomas</a>.”</p><p></p><p>For more information on high grade gliomas, please see:</p><ul><li> <a href="/Article?contentid=1312&language=English">High Grade Gliomas</a></li> <li> <a href="/Article?contentid=1326&language=English">Diagnosis of High Grade Gliomas</a></li></ul> <br>Treatment of high grade gliomas

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