Subtypes of AMLSSubtypes of AMLSubtypes of AMLEnglishOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MD000Flat ContentHealth A-Z<p> Learn about the different subtypes of acute myeloid leukemia (AML) and how they are diagnosed.</p><p>There are 8 different subtypes of acute myeloid leukemia (AML). When your child is diagnosed with AML, doctors do a bone marrow aspirate test to determine the subtype.</p><h2> Key points </h2> <ul><li> AML occurs when a change in the DNA of the stem cell stops it from developing normally.</li> <li> Abnormalities in chromosomes can cause AML.</li> <li> AML is classified based on genetic changes in leukemia cells.</li> <li> Your child's AML subtype helps doctors understand how to treat the disease.</li> <li> Most subtypes of AML follow similar treatment protocols.</li></ul>
Sous-types de leucémie myéloblastique aiguëSSous-types de leucémie myéloblastique aiguëSubtypes of AMLFrenchOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MDFlat ContentHealth A-Z<p>Récouvrez les différents sous-types de leucémie myéloblastique aiguë (LMA) et comment ils sont diagnostiqués.</p><p>Il existe huit différents sous-types de leucémie myéloblastique aiguë (LMA). Quand une LMA est diagnostiquée chez votre enfant, les médecins font une ponction de sa moelle osseuse pour déterminer le sous-type de LMA.</p><h2>À retenir</h2><ul><li>La LMA se produit lorsqu’un changement dans l’ADN de la cellule souche l’empêche de se développer normalement.</li><li>Les anomalies des chromosomes peuvent causer la LMA.</li><li>La LMA est classifiée en fonction des changements génétiques dans les cellules leucémiques.</li><li>Le sous-type de LMA de votre enfant aide les médecins à comprendre comment traiter la maladie.</li><li>La plupart des sous-types de LMA suivent des protocoles de traitement similaires.</li></ul>

 

 

Subtypes of AML2831.00000000000Subtypes of AMLSubtypes of AMLSEnglishOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MD000Flat ContentHealth A-Z<p> Learn about the different subtypes of acute myeloid leukemia (AML) and how they are diagnosed.</p><p>There are 8 different subtypes of acute myeloid leukemia (AML). When your child is diagnosed with AML, doctors do a bone marrow aspirate test to determine the subtype.</p><h2> Key points </h2> <ul><li> AML occurs when a change in the DNA of the stem cell stops it from developing normally.</li> <li> Abnormalities in chromosomes can cause AML.</li> <li> AML is classified based on genetic changes in leukemia cells.</li> <li> Your child's AML subtype helps doctors understand how to treat the disease.</li> <li> Most subtypes of AML follow similar treatment protocols.</li></ul><h2>How your child's AML subtype is determined</h2><p>After taking a sample of your child’s marrow, lab specialists look at two different biological features: the type of blood cell involved, and the chromosomes.</p><h3>The type of blood cell that has become cancerous</h3><p>AML occurs when the DNA inside a young blood cell (myeloid cell) in the bone marrow changes so that it cannot develop into a mature blood cell. Cancerous myeloid cells are also called "leukemic myeloblasts." </p><p>Normally, myeloid cells develop into different type of blood cells. These include:</p><ul><li>monocytes, which develop further into white blood cells called macrophages. These cells help our body fight infection.</li><li>erythrocytes (red cells)</li><li> platelets</li></ul><p>AML can occur in any one of these cell types.<br></p> <figure> <span class="asset-image-title">Blood cell </span> <span class="asset-image-title">development</span><img src="https://assets.aboutkidshealth.ca/akhassets/Blood_cell_development_MED_ILL_EN.jpg" alt="" /><figcaption class="asset-image-caption">All</figcaption><figcaption class="asset-image-caption"> blood cells develop from one type of cell, called a primitive stem cell. Stem cells are found primarily in the bone marrow, but also in circulating blood and in a baby’s umbilical cord. In AML and ALL, there is a change in the DNA of the stem cell that stops it from developing normally.</figcaption> </figure> <h3>Abnormal chromosomes </h3><p>Chromosomes are long lengths of DNA inside cells. In a healthy cell, there are normally 46 copies of chromosomes. There are two copies of each chromosome. Each pair is numbered 1 through to 23. </p> <figure><span class="asset-image-title">Chromosomal Translocation</span><img src="http://assets.aboutkidshealth.ca/akhassets/Chromosomal_translocation_MED_ILL_EN.jpg" alt="" /> </figure><figure> <img src="http://assets.aboutkidshealth.ca/akhassets/Chromosomal_inversion_MED_ILL_EN.jpg" alt="" /> </figure> <p>Abnormalities in chromosomes can cause AML. These abnormalities include:</p><ul><li> Chromosome translocation, which happens when a part of a chromosome separates itself and sticks onto another, unrelated chromosome. </li><li> Chromosome inversion, which happens when part of a chromosome turns upside down.</li></ul><p>Both processes produce new chromosomes that express genes in different ways, and can lead to AML.</p><h2>What are the AML subtypes?</h2><p>The older French American British (FAB) classification system subdivided AML according to the type of cell that becomes cancerous. This system classified AML into 8 different subtypes, ranging from AML M0 to M7. </p> <figure> <img src="http://assets.aboutkidshealth.ca/akhassets/Chromosomal_inversion_MED_ILL_EN.jpg" alt="" /> </figure> <p>The World Health Organization (WHO) updated its classifications of AML in 2016 based on genetic changes in the leukemia cells, including:</p><ul><li>AML with recurrent genetic abnormalities</li><li>AML with myelodysplasia-related features </li><li> Therapy-related myeloid neoplasms</li><li> AML, not otherwise specified</li><li>Myeloid sarcoma</li><li>Myeloid proliferations related to Down syndrome:</li><ul><li>Transient abnormal myelopoiesis (TAM)</li><li>Myeloid leukemia associated with Down syndrome.</li></ul><li>Blastic plasmacytoid dendritic cell neoplasm (BPDCN). </li></ul><h2>Why is it important to know your child’s AML subtype?</h2><p>Your child’s AML subtype helps doctors understand how best to treat the disease. It also predicts the likely prognosis of your child’s leukemia. </p><p>All the subtypes of AML follow similar treatment protocols, except subtype M3 or APL.</p> <br>Subtypes of AML

Thank you to our sponsors

AboutKidsHealth is proud to partner with the following sponsors as they support our mission to improve the health and wellbeing of children in Canada and around the world by making accessible health care information available via the internet.