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ThioguanineTThioguanineThioguanineEnglishPharmacyNANANADrugs and SupplementsCaregivers Adult (19+)NA2016-06-01T04:00:00ZRita V. Kutti, BScPhm, RPh65.00000000000008.000000000000001450.00000000000Drugs (A-Z)Drug A-Z<p>Your child needs to take the medicine called thioguanine. This information sheet explains what thioguanine does, how to give it, and what side effects or problems your child may have when he takes this medicine.</p><p>Your child needs to take the medicine called thioguanine (say: thye-oh-GWAN-neen). This information sheet explains what thioguanine does, how to give it, and what side effects or problems your child may have when they take this medicine.</p><h2>Before giving thioguanine to your child</h2> <p>Tell your child's doctor if:</p> <ul><li>your child has ever reacted badly to thioguanine or to any other medication, food, preservatives, or colouring agents</li> <li>your child has ever been treated with thioguanine or <a href="/Article?contentid=182&language=English">mercaptopurine</a> in the past</li></ul> <h3>Talk with the doctor or pharmacist if your child has any of the following conditions. Precautions may need to be taken with this medicine if your child has:</h3> <ul><li>infection or recent exposure to infection (for example chickenpox)</li> <li>liver or kidney problems</li> <li>low blood counts</li> <li>thiopurine methyltransferase deficiency (TPMT)</li></ul><h2>How should you give your child thioguanine?</h2><p>Follow these instructions when you give your child this medicine:</p><ul><li>Give your child thioguanine for as long as your doctor or pharmacist tells you, even if your child seems better. Talk to your child's doctor before you stop giving this medicine for any reason.</li><li>Give your child thioguanine at the same time and the same way (either with or without food) each day it is prescribed.</li><li>If your child has difficulty swallowing thioguanine tablets, review the options with the pharmacist. Tablets should NOT be crushed.</li><li>Consider wearing gloves and a mask when handling thioguanine. Always wash your hands after each dose that you give your child.</li><li>If your child vomits (throws up) within 20 to 30 minutes of taking a dose, give another dose. If your child vomits again, do not give any further doses. Contact the doctor or clinic nurse the next morning to let them know.</li></ul><h2>What should you do if your child misses a dose of thioguanine?</h2> <ul><li>Give the missed dose as soon as you remember.</li> <li>If it is almost time for the next dose, skip the missed dose. Give the next dose at the regular time.</li> <li>Do not give your child 2 doses to make up for 1 missed dose.</li></ul><h2>What are the possible side effects of thioguanine?</h2> <p>Your child may have some of these side effects while they take thioguanine. Check with your child's doctor if your child continues to have any of these side effects, and they do not go away, or they bother your child:</p> <ul><li>loss of appetite</li> <li>weight loss</li> <li>loose stools (diarrhea)</li> <li>mild nausea (upset stomach) and vomiting (throwing up)</li> <li>skin rash or itching</li></ul> <p>Call your child's doctor during office hours if your child has any of these side effects:</p> <ul><li>joint pain</li> <li>swelling of feet or lower legs</li> <li>unsteadiness when walking</li> <li>sores in mouth and on lips</li> <li>yellow eyes or skin</li> <li>sudden weight gain</li></ul> <h3>Most of the following side effects are not common, but they may be a sign of a serious problem. Call your child's doctor right away or take your child to Emergency if your child has any of these side effects:</h3> <ul><li>fever or chills</li> <li>cough or sore throat</li> <li>severe diarrhea</li> <li>severe abdominal pain</li> <li>black, tarry stools</li> <li>blood in urine or stools</li> <li>difficulty with urination or pain with urination</li> <li>lower back or side pain</li> <li>pinpoint red spots on skin</li> <li>unusual bruising or bleeding</li></ul><h2>What safety measures should you take when your child is using thioguanine?</h2> <p>Keep all appointments at the clinic or doctor's office so that the doctor can check your child's response to thioguanine. The doctor may need to change the dose of thioguanine from time to time.</p> <p>Your child's doctor will order blood tests to check for problems with the liver and blood while your child is getting thioguanine.</p> <p>Tell your doctor or dentist that your child is receiving thioguanine before your child has any operation, even on the teeth, or an emergency treatment.</p> <p>Thioguanine can lower the number of white blood cells in the blood temporarily, which increases your child's chances of getting an infection. Your child can take the following precautions to prevent infections, especially when the blood count is low:</p> <ul><li>Avoid people with infections, such as a cold or the flu.</li> <li>Avoid places that are very crowded with large groups of people.</li> <li>Be careful when brushing or flossing your child's teeth. Your doctor, nurse, or dentist may suggest different ways to clean your child's mouth and teeth.</li> <li>You and your child should not touch your child's eyes or inside the nose without washing hands first.</li> <li>Your child's nurse will review with you what to do in case of fever.</li></ul> <p>Thioguanine can lower the number of platelets in the blood, which increases your child's risk of bleeding. You can take the following precautions:</p> <ul><li>Be careful not to cut your child when using a razor, fingernail scissors or toenail clippers.</li> <li>Be careful when shaving or waxing.</li> <li>Your child should avoid contact sports where bruising or injury could occur.</li> <li>Your child should not receive a permanent tattoo or any kind of body piercing.</li> <li>Before your child has surgery, including dental surgery, inform the doctor or dentist that your child is taking thioguanine.</li></ul> <p>Your child should not receive any immunizations (vaccines) without your child's doctor's approval. Your child or anyone else in your household should not get oral polio vaccine while your child is being treated for cancer. Tell your child's doctor if anyone in your household has recently received oral polio vaccine. Your child should avoid contact with anyone who has recently received this vaccine. Other live vaccines that your child should not get include measles, mump and rubella (MMR) and chicken pox vaccine.</p> <p>Thioguanine may cause sores in the mouth. Rinse your child's mouth with a mouthwash made from baking soda to help keep it clean. Your nurse or pharmacist can review this with you. Avoid store-bought mouthwash as it may sting and cause dry mouth.</p> <p>There is a chance that thioguanine may cause birth defects if it is taken at the time of conception or if it is taken during pregnancy. If your child is sexually active, it is best that they use some kind of birth control while receiving thioguanine. Tell the doctor right away if your child may be pregnant.</p> <p>Check with your child's doctor or pharmacist before giving your child any other medicines (prescription, non-prescription, herbal or natural products).</p><h2>What other important information should you know about thioguanine?</h2><ul><li>Thioguanine does not normally cause hair loss.</li><li>Keep a list of all medications your child is on and show the list to the doctor or pharmacist.</li><li>Do not share your child's medicine with others and do not give anyone else's medicine to your child.</li><li>Thioguanine may make your child's skin more likely to sunburn. Make sure your child covers their skin and head with clothing and a hat. Or use a strong sunscreen (a cream that protects the skin from the sun). Look for a sunscreen that says it protects against the sun's ultraviolet rays, called UVA and UVB rays. The sunscreen should have a sun protection factor (SPF) of at least 15. Ask your pharmacist to help you pick the right sunscreen.</li><li>Make sure you always have enough thioguanine to last through weekends, holidays, and vacations. Call your pharmacy at least 2 days before your child runs out of medicine to order refills. Not all pharmacies will carry thioguanine.</li><li>Keep thioguanine at room temperature in a cool, dry place away from sunlight. Do NOT store it in the bathroom or kitchen.</li><li>Do not keep any medicines that are out of date. Check with your pharmacist about the best way to throw away outdated or leftover medicines.<br></li></ul>
硫鸟嘌呤硫鸟嘌呤ThioguanineChineseSimplifiedPharmacyNANANADrugs and SupplementsCaregivers Adult (19+)NA2010-03-25T04:00:00ZRita V. Kutti, BScPhm, RPh​Flat ContentDrug A-Z<p>你的孩子需要使用称为硫鸟嘌呤的药物。此信息篇解释硫鸟嘌呤做什么和如何给予,以及当你的孩子使用这种药物的时候,他可能有的副作用或问题。</p>

 

 

硫鸟嘌呤251.000000000000硫鸟嘌呤ThioguanineChineseSimplifiedPharmacyNANANADrugs and SupplementsCaregivers Adult (19+)NA2010-03-25T04:00:00ZRita V. Kutti, BScPhm, RPh​Flat ContentDrug A-Z<p>你的孩子需要使用称为硫鸟嘌呤的药物。此信息篇解释硫鸟嘌呤做什么和如何给予,以及当你的孩子使用这种药物的时候,他可能有的副作用或问题。</p><h2>这是什么药?</h2><p>硫鸟嘌呤是用来杀死癌细胞的药物。它阻止细胞分裂和产生新的细胞。</p><p>你可能听到过硫鸟嘌呤称为6-TG,或其商品名称Lanvis®。硫鸟嘌呤为片剂型。 </p><h2>在给予你的孩子这种药物之前 </h2><p>告诉你孩子的医生,如果:</p><ul><li> 你的孩子曾经对硫鸟嘌呤或任何其他药品、食品、防腐剂,或着色剂有过严重反应 </li><li> 你的孩子在过去接受过硫鸟嘌呤或巯基嘌呤的治疗</li></ul><h3>如果你的孩子有任何下列疾病,告知你的孩子的医生或药剂师。如果你的孩子有下列疾病,使用这种药物可能需要采取预防措施:</h3><ul><li> 感染或最近接触感染,(例如水痘)</li><li> 肝脏或肾脏问题</li><li> 低血计数</li><li> 巯基嘌呤甲基转移酶缺乏症(TPMT)</li></ul><h2>你应该如何给予你的孩子这种药物?</h2><p>当你给你的孩子这种药物时,按照这些指示:</p><ul><li> 正确地按照你的医生或药剂师告诉你的指示,给予你的孩子硫鸟嘌呤。出于任何原因,你停止给予这种药物之前,与你的孩子的医生协商。.</li><li> 每天在同一时间给予你的孩子硫鸟嘌呤。如果你的孩子服用硫鸟嘌呤,每天一次,最好是在睡前给予,除非你的医生告诉你其他说明。</li><li> 空腹(饭前一小时或饭后两小时),用一杯水,给予这种药物。</li><li> 不要与牛奶、酸奶、冰淇淋、布丁,或其他奶制品一起给予硫鸟嘌呤。你的孩子不能在服用硫鸟嘌呤前2小时和硫鸟嘌呤后1小时食用任何乳制品。你的孩子可能在用药日子的其他时间食用牛奶和其他乳制品。</li><li> 如果你的孩子有困难吞咽硫鸟嘌呤片剂,与药剂师协商选项。不应该碾碎片剂。</li><li> 在处理硫鸟嘌呤时,考虑戴手套和口罩。在你给你的孩子每一个剂量后,总是洗手。</li><li> 如果你的孩子服用剂量后20到30分钟内呕吐,给予另一剂量。如果你的孩子再次呕吐,不要给予进一步任何剂量。在第二天早晨,联系医生或门诊护士,让他/她们知道。</li></ul><h2>如果你的孩子错过了剂量,你应该怎么做?</h2><ul><li> 一旦想起来,马上补服错过的剂量。</li><li> 如果几乎是下一个用药的时间,跳过错过的剂量。在正常的时间给予下一个剂量。</li><li> 不要用给予你的孩子两个剂量来弥补一个错过的剂量。</li></ul><h2>这种药物的可能的副作用是什么?</h2><p>当你的孩子使用硫鸟嘌呤时,他或她可能有一些副作用。如果你的孩子继续有任何下面副作用,而且它们没有消失,或者它们烦扰你的孩子,与你的孩子的医生协商:</p><ul><li> 食欲不振</li><li> 体重减轻</li><li> 稀的大便(腹泻)</li><li> 轻度恶心(胃部不适)和呕吐</li><li> 皮肤出疹或发痒</li></ul><p>如果你的孩子有任何这些副作用,在办公时间致电你的孩子的医生:</p><ul><li> 关节疼痛</li><li> 脚或小腿肿胀</li><li> 走路不稳</li><li> 口腔和嘴唇溃疡</li><li> 眼睛或皮肤发黄</li><li> 体重突然增加</li></ul><h3>大多数这些副作用是不常见的,但是,它们可能是一个严重问题的征兆。如果你的孩子有任何以下这些症状,立刻打电话给你的孩子的医生,或带你的孩子去急诊:</h3><ul><li> 发烧或发冷</li><li> 咳嗽或喉咙疼痛</li><li> 严重腹泻</li><li> 严重腹部疼痛</li><li> 黑色柏油样大便</li><li> 尿液或大便中有血</li><li> 排尿困难或排尿疼痛</li><li> 腰部或侧面疼痛</li><li> 皮肤上有小的红色斑点</li><li> 不寻常的出血或瘀伤</li></ul><h2>当你的孩子使用这种药物时,你应该采取什么安全措施? </h2><p>保持在门诊或医生办公室的所有预约,这样医生可以检查你的孩子对硫鸟嘌呤的反应。医生可能需要不时调整你的孩子的剂量。</p><p>你的孩子使用硫鸟嘌呤时,你的孩子的医生将制定做血液测试,以检查肝脏和血液问题。</p><p>在你的孩子做任何手术,即使是牙齿手术,或一个紧急治疗之前,告诉医生或牙医你的孩子正在使用硫鸟嘌呤。</p><p>硫鸟嘌呤可能暂时降低血液中白血球的数量,增加了你的孩子受感染的机会。你的孩子可以采取以下措施,以预防感染,特别是当血液计数低的时候:</p><ul><li> 避免接触有感染的人,比如感冒或流感。</li><li> 避免到有大量人群非常拥挤的地方。</li><li> 当刷牙或使用牙线清洁你的孩子的牙齿时,要小心。你的医生、护士,或牙医可能会建议不同的方法来清洁你的孩子的口腔和牙齿。</li><li> 没有首先洗手,你和你的孩子不应该接触你的孩子的眼睛或鼻子里。</li><li> 你的孩子的护士将与你讨论万一发烧的情况下,你做什么。</li></ul><p>硫鸟嘌呤可以降低血液中的血小板数量,从而增加你的孩子出血的风险。你可以采取以下预防措施:</p><ul><li> 当使用剃刀、指甲刀,或脚趾指甲刀剪的时候,小心不要刺伤你的孩子。</li><li> 剃须或打蜡时,要小心。</li><li> 你的孩子应该避免可能发生瘀伤或受伤的接触性运动。</li><li> 你的孩子不应该接受永久性纹身或任何类型的身体穿孔。</li><li> 在你的孩子做手术之前,包括牙科手术,告诉医生或牙医你的孩子正在使用硫鸟嘌呤。</li></ul><p>没有你的孩子的医生的批准,你的孩子不应该接受任何预防接种(疫苗)。当你的孩子正在接受癌症治疗时,你的孩子或你的家庭中的任何其他人不应该接受口服脊髓灰质炎疫苗。如果你的家庭中的任何人最近接受了口服脊髓灰质炎疫苗,告诉你的孩子的医生。你的孩子应该避免接触任何最近接受了这种疫苗的人。你的孩子不应该接种的其它活疫苗包括:麻疹、腮腺炎和风疹联合疫苗(MMR)和水痘疫苗。</p><p>硫鸟嘌呤可能造成口腔溃疡。使用小苏打漱口水冲洗你的孩子的嘴,以帮助保持干净。你的护士或药剂师可以告诉你这一点。不要使用商店购买的漱口水,因为它可能刺痛,并导致口干。</p><p>如果在受孕时,或者如果在怀孕期间使用硫鸟嘌呤,有可能有导致出生缺陷的机会。如果你的孩子是性活跃的,当接受硫鸟嘌呤的时候,他或她最好使用某种类型的节育措施。如果你的孩子可能怀孕,立即告诉你的医生。</p><p>在给予你的孩子任何其它药物(处方药、非处方药、草药或天然产品)之前,与你的孩子的医生或药剂师协商。</p><h2>你还应该知道其它什么重要信息?</h2><p>硫鸟嘌呤通常不会引起脱发。 </p><p>保留一个列有你的孩子正在使用的所有药物的清单,向医生或药剂师出示这个清单。</p><p>不要将你的孩子的药物与其他人共享。不要给予你的孩子任何其他人的药物。</p><p>硫鸟嘌呤可能会使你的孩子的皮肤更容易晒伤。确保你的孩子穿好衣服和戴帽子覆盖他或她的皮肤和头部,或使用一个强的防晒霜(防止皮肤被太阳晒伤的霜)。检查防晒霜防护太阳紫外线,既UVA及UVB的信息。防晒霜的防晒系数,称为SPF,至少应是15。询问你的药剂师,以帮助你选择正确的防晒霜。</p><p>在周末、节假日和休假期间,确保你总是有足够的硫鸟嘌呤。在你的孩子用完药物至少2天之前,致电联络你的药房订购续药。并非所有的药店都将有硫鸟嘌呤。</p><p>把硫鸟嘌呤保存在室温下阴凉干燥避免阳光照射的地方。不要把药物储存在卫生间或厨房。</p><p>不保留任何已经过期的药物。与你的药剂师协商扔掉过期或剩余药品的最佳方式。</p><p>把硫鸟嘌呤保存在你的孩子看不见和接触不到的地方,并锁在一个安全的地方。如果你的孩子使用了过量的硫鸟嘌呤,拨打以下电话之一与安大略省中毒中心联系。这些电话都是免费的。</p><ul><li>如果你住在多伦多, 致电416-813-5900。</li><li>如果你住在安大略省的其它地区, 致电1-800-268-9017。 </li><li>如果你住在安大略省以外,致电当地的中毒信息中心。 </li></ul><p>免责声明:本家庭医学援助中的信息在付印时是准确的。它提供了有关硫鸟嘌呤的信息摘要, 不包含有关此药的所有可能的信息。没有列出所有的副作用。如果你有任何疑问或想了解更多有关硫鸟嘌呤的信息, 告诉你的医护人员。 </p>https://assets.aboutkidshealth.ca/AKHAssets/ICO_DrugA-Z.png硫鸟嘌呤False

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