High grade gliomasHHigh grade gliomasHigh grade gliomasEnglishNeurology;OncologyChild (0-12 years);Teen (13-18 years)Brain;SpineNervous systemConditions and diseasesAdult (19+)NA2009-07-10T04:00:00ZEric Bouffet, MD, FRCPCUri Tabori, MD000Flat ContentHealth A-Z<p>In-depth information about high grade gliomas, their causes, and some of the medical symptoms of this type of tumour.<br></p><p>High grade gliomas can occur in different parts of the central nervous system and they can affect children of any age. The tumours most often originate in the supratentorial region of the brain (the part of the brain that we use) and the brain stem. High grade gliomas coming from the supratentorial region are often called supratentorial high grade gliomas. High grade gliomas are also called anaplastic astrocytomas.</p><h2>Key points</h2> <ul><li>High grade means that the glioma is growing rapidly.</li> <li>High grade gliomas account for 15% to 20% of all central nervous system tumours in children.</li> <li>Symptoms of high grade gliomas vary depending on which area of the brain is involved.</li></ul>
Gliomes de haute gradeGGliomes de haute gradeHigh grade gliomasFrenchNeurology;OncologyChild (0-12 years);Teen (13-18 years)Brain;SpineNervous systemConditions and diseasesAdult (19+)NA2009-07-10T04:00:00ZEric Bouffet, MD, FRCPCUri Tabori, MD000Flat ContentHealth A-Z<p>Renseignements sur les gliomes de haut grade.</p><p>Les gliomes de haut grade peuvent atteindre diverses parties du système nerveux central et ils peuvent affecter des enfants de tout âge. La plupart du temps, les tumeurs proviennent de la région de la face supérieure de la tente du cervelet (la partie de l’encéphale que nous utilisons) et du tronc cérébral. On appelle souvent les gliomes de haut grade de la région de la face supérieure de la tente du cervelet les gliomes de haut grade sustentoriels. Les gliomes de haut grade se nomment aussi astrocytomes anaplasiques.</p><h2>À retenir</h2> <ul><li>L'expression « haut grade » signifie que le gliome croît rapidement.</li> <li>Les gliomes de haut grade représentent de 15 à 20 % de toutes les tumeurs du système nerveux central chez les enfants.</li> <li>Les symptômes des gliomes de haut grade varient en fonction de la région de l’encéphale touchée.</li></ul>

 

 

High grade gliomas1312.00000000000High grade gliomasHigh grade gliomasHEnglishNeurology;OncologyChild (0-12 years);Teen (13-18 years)Brain;SpineNervous systemConditions and diseasesAdult (19+)NA2009-07-10T04:00:00ZEric Bouffet, MD, FRCPCUri Tabori, MD000Flat ContentHealth A-Z<p>In-depth information about high grade gliomas, their causes, and some of the medical symptoms of this type of tumour.<br></p><p>High grade gliomas can occur in different parts of the central nervous system and they can affect children of any age. The tumours most often originate in the supratentorial region of the brain (the part of the brain that we use) and the brain stem. High grade gliomas coming from the supratentorial region are often called supratentorial high grade gliomas. High grade gliomas are also called anaplastic astrocytomas.</p><h2>Key points</h2> <ul><li>High grade means that the glioma is growing rapidly.</li> <li>High grade gliomas account for 15% to 20% of all central nervous system tumours in children.</li> <li>Symptoms of high grade gliomas vary depending on which area of the brain is involved.</li></ul><h2>What is a high grade glioma?</h2><p>A glioma is a name for tumours of the glial cells. These are the supporting cells of the nervous system. Gliomas can arise in any part of the brain and may also be found in the spinal cord. More than half of all brain tumours in children are gliomas. There are different types of gliomas. Physicians use the terms “glioma” and “astrocytoma” interchangeably.</p><p>High grade means that the glioma is growing rapidly. High grade gliomas are either World Health Organization (WHO) grade 3 tumours or grade 4. Grade 3 and 4 tumours tend to grow rapidly and spread faster than tumours of a lower grade.</p><p>The most common grade 3 tumour is anaplastic astrocytoma and the most common grade 4 tumour is glioblastoma multiforme. Other more complex high grade gliomas include: oligoastrocytoma, pleiomorphic xanthoastrocytoma, and gliosarcoma.</p><p>When arising from the brainstem, high grade gliomas are usually referred to as diffuse brainstem gliomas or diffuse pontine gliomas.<br></p><h2>What causes high grade gliomas?</h2><p>There is little information available about how supratentorial high grade gliomas form. However, scientists have found that there are certain genetic abnormalities associated with these types of tumours.</p><h2>How many other children have high grade gliomas?</h2><p>Overall, high grade gliomas account for 15% to 20% of all central nervous system tumours in children. Supratentorial high grade gliomas make up about 6% to 12% of all brain tumours in children. They occur much more frequently in teenagers than in very young children. Diffuse brainstem gliomas comprise about 3% to 9% of all brain tumours in children. This type of tumour tends to affect children around six or seven years of age most often.</p><p>Each year, 150 to 180 children in North America are diagnosed with a high grade glioma. In Europe, 250 children are diagnosed with this type of tumour each year.</p><p>High grade gliomas occur equally between boys and girls and among children of different ages.</p><h2>What are some medical symptoms of high grade gliomas?</h2><h3>Supratentorial high grade gliomas</h3><p>Children with supratentorial high grade gliomas show signs and symptoms that depend on which area of the brain is involved. There may be neurological deficits, seizures, accompanied by signs and symptoms of increased intracranial pressure:</p><ul><li>Headaches, mostly in the morning</li><li>Nausea and vomiting, mostly in the morning</li><li>Blurred or decreased vision</li><li>Sluggishness or drowsiness</li><li>Changes in behaviour</li><li>Seizures</li><li>In infants: a bulging fontanelle (soft spot) or increased skull size</li></ul><h3>Brainstem gliomas</h3><p>For information about the symptoms of this type of tumour, see the page entitled “<a href="/Article?contentid=1311&language=English">Diffuse Pontine Gliomas</a>.”</p><p>For more information please see:</p><ul><li> <a href="/Article?contentid=1326&language=English">Diagnosis of High Grade Gliomas</a></li><li> <a href="/Article?contentid=1362&language=English">Treatment of High Grade Gliomas</a><br></li></ul> <br>High grade gliomas

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