Understanding insulinUUnderstanding insulinUnderstanding insulinEnglishEndocrinologyChild (0-12 years);Teen (13-18 years)PancreasEndocrine systemDrug treatmentAdult (19+)NA2016-10-17T04:00:00ZCatherine Pastor, RN, MN, HonBSc;Vanita Pais, RD, CDE;Jennifer Harrington​, MBBS, PhD​000Flat ContentHealth A-Z<p>Learn where injectable insulin comes from and how it works.</p><h2>Where does injectable insulin come from?</h2> <p>Insulin was first isolated and collected from the pancreases of cows and pigs for use in humans with diabetes. Since 1983, however, a product called biosynthetic human insulin has been available. This insulin is produced in a laboratory by introducing a man-made human gene into bacteria or yeast. This process produces insulin that is almost exactly the same as that created in the human pancreas.</p> <p>Through further changes, man-made altered forms of insulin (called insulin analogs) differ from naturally incurring insulin by having different action times. Today, all children and nearly all adults with diabetes receive biosynthetic human insulin products and insulin analogs.</p><h2>Key points</h2> <ul><li>All children and nearly all adults with diabetes receive biosynthetic human insulin products and insulin analogs.</li> <li>Insulin is available in premixed doses that combine rapid -acting insulin with intermediate-acting insulin in fixed proportions.</li></ul>
Comprendre l’insulineCComprendre l’insulineUnderstanding insulinFrenchEndocrinologyChild (0-12 years);Teen (13-18 years)PancreasEndocrine systemDrug treatmentAdult (19+)NA2016-10-17T04:00:00ZCatherine Pastor, RN, MN, HonBSc;Vanita Pais, RD, CDE;Jennifer Harrington​, MBBS, PhD​000Flat ContentHealth A-Z<p>Découvrez l’origine de l’insuline injectable et son mode d’action.</p><h2>D’où provient l’insuline injectable?</h2> <p>L’insuline a tout d’abord été isolée et prélevée du pancréas des bovins et des porcs pour une utilisation chez les humains atteints du diabète. Cependant, depuis 1983, on peut trouver sur le marché un produit appelé insuline humaine biosynthétique. Cette insuline est produite dans un laboratoire par l’introduction d’un gène humain synthétique (fabriqué par l’homme) dans une bactérie ou de la levure. Ce processus produit de l’insuline qui correspond parfaitement à celle que fabrique le pancréas humain.</p> <p>À la suite d'autres modifications, les types modifiées d’insuline synthétique (appelées analogues) ont des délais d’action différents de l’insuline naturelle. Maintenant, tous les enfants et presque tous les adultes atteints du diabète prennent des produits d’insuline humaine biosynthétique et des analogues.</p><h2>À retenir</h2> <ul><li>Tous les enfants et presque tous les adultes diabétiques prennent des produits d’insuline humaine biosynthétique et des analogues.</li> <li>L’insuline se présente en format prémélangé de proportions fixes d’insuline à action rapide et d'insuline à action intermédiaire.</li></ul>

 

 

Understanding insulin1729.00000000000Understanding insulinUnderstanding insulinUEnglishEndocrinologyChild (0-12 years);Teen (13-18 years)PancreasEndocrine systemDrug treatmentAdult (19+)NA2016-10-17T04:00:00ZCatherine Pastor, RN, MN, HonBSc;Vanita Pais, RD, CDE;Jennifer Harrington​, MBBS, PhD​000Flat ContentHealth A-Z<p>Learn where injectable insulin comes from and how it works.</p><h2>Where does injectable insulin come from?</h2> <p>Insulin was first isolated and collected from the pancreases of cows and pigs for use in humans with diabetes. Since 1983, however, a product called biosynthetic human insulin has been available. This insulin is produced in a laboratory by introducing a man-made human gene into bacteria or yeast. This process produces insulin that is almost exactly the same as that created in the human pancreas.</p> <p>Through further changes, man-made altered forms of insulin (called insulin analogs) differ from naturally incurring insulin by having different action times. Today, all children and nearly all adults with diabetes receive biosynthetic human insulin products and insulin analogs.</p><h2>Key points</h2> <ul><li>All children and nearly all adults with diabetes receive biosynthetic human insulin products and insulin analogs.</li> <li>Insulin is available in premixed doses that combine rapid -acting insulin with intermediate-acting insulin in fixed proportions.</li></ul><h2>Insulin strength and packaging</h2><p>In North America, insulin is usually produced at a concentration of 100 units/mL. Before giving insulin to your child, make sure to check the concentration. Insulin is available in three ways:</p><table class="akh-table"><thead><tr><th style="width:25%;">Vial<br></th><th style="width:35%;">Cartridges</th><th style="width:40%;">Preloaded disposable pens</th></tr></thead><tbody><tr></tr><tr><td><ul><li>Used with needles (syringes);<br></li><li>Each vial holds 10 mL of insulin.</li></ul></td><td><ul><li>Used with insulin pen or insulin pumps;</li><li>Each pen cartridge holds 3 mL of insulin.</li></ul></td><td><ul><li>Each pen has a preloaded cartridge that hold 3 mL of insulin.</li></ul></td></tr><tr><td> <img alt="insulin vial illustration" src="https://assets.aboutkidshealth.ca/akhassets/IMN_insulin_packaging_vial_EN.png" /> </td><td> <img alt="insulin cartridge illustration" src="https://assets.aboutkidshealth.ca/akhassets/IMN_insulin_packaging_cartridges_EN.png" /> </td><td> <img alt="insulin preloaded disposable pen illustration" src="https://assets.aboutkidshealth.ca/akhassets/IMN_insulin_packaging_pen_EN.png" /> </td></tr></tbody></table><h2>Insulin action times</h2><p>Insulin analogs are generally described as:</p><ul><li>rapid-acting (also referred to as fast-acting)</li><li>intermediate-acting</li><li>long-acting.</li></ul><p>Insulin analogs are also described according to their course of action:</p><ul><li> <strong>Onset</strong> is the time it takes for the insulin to start working.</li><li> <strong>Peak</strong> describes the period when the insulin is working at its strongest.</li><li> <strong>Duration</strong> describes the length of time before the effect of the dose wears off.</li></ul> <figure><img src="https://assets.aboutkidshealth.ca/akhassets/IMN_insulin_actions_times_EN.png" alt="" /> </figure> <h2>Premixed insulin</h2><p>Insulin is available in premixed doses that combine rapid -acting insulin with intermediate-acting insulin in fixed proportions. Premixed insulin is generally not recommended for children, because it does not allow for any flexibility in insulin dose adjustments and, therefore, does not allow for better blood sugar control compared to other insulin routines.</p>https://assets.aboutkidshealth.ca/akhassets/IMN_insulin_packaging_vial_EN.pngUnderstanding insulin

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