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Subtypes of ALLSSubtypes of ALLSubtypes of ALLEnglishOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MD000Flat ContentHealth A-Z<p>Acute lymphoblastic leukemia (ALL) can be broken down into different subtypes. Learn about the subtypes of ALL and how they are identified.</p><p>Lymphocytes are white blood cells that help the body defend against disease. There are different types of lymphocytes, which include B-lymphocytes and T-lymphocytes.</p> <p>Acute lymphoblastic leukemia (ALL) occurs when the DNA inside an immature lymphocyte (lymphoblast) changes. This mutation can happen at different developmental stages of the lymphocyte. Depending on whether the genetic change takes place in a developing B-lymphocyte or T-lymphocyte, ALL can be further broken down into different subtypes. Identifying your child’s ALL subtype will help doctors decide their treatment plan.</p><h2> Key points </h2> <ul><li>ALL can be classified as B-lymphoblastic leukemia or T-lymphoblastic leukemia, but can be further broken down into different subtypes.</li> <li>Identifying your child’s ALL subtype will help doctors plan their treatment.</li> <li>Precursor B-cell ALL is the most common subtype of ALL.</li> <li>Immunophenotyping (or flow cytometry) tests can diagnose ALL subtypes.</li></ul>
Sous-types de leucémie lymphoblastique aiguëSSous-types de leucémie lymphoblastique aiguëSubtypes of ALLFrenchOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MDFlat ContentHealth A-Z<p>La leucémie lymphoblastique aiguë (LLA) peut être décomposée en différents sous-types. Renseignez-vous sur les sous-types de LLA et comment ils sont identifiés.</p><p>Les lymphocytes sont des globules blancs qui aident le corps à se défendre contre la maladie. Il existe deux types de lymphocytes : les lymphocytes B et les lymphocytes T.</p><p>La leucémie lymphoblastique aiguë (LLA) survient quand l’ADN d’un globule blanc immature (lymphoblaste) subit une mutation. Cette mutation peut se produire à différentes étapes de développement de la cellule. Selon le type de lymphocyte où la mutation a eu lieu, la LLA peut être répartie en différents sous-types. Le fait de connaître le sous-type de la LLA de votre enfant aidera les médecins à élaborer le plan de traitement.</p><h2> À retenir </h2><ul><li>La LLA peut être classée en leucémie lymphoblastique de type B ou en leucémie lymphoblastique de type T, mais peuvent être subdivisés en différents sous-types.</li><li>Identifier le sous-type de LLA de votre enfant aidera les médecins à planifier son traitement.</li><li> La LLA à précurseurs de cellules B est le sous-type le plus commun de la LLA.</li><li>Les tests d’immunophénotypage (ou de cytométrie de flux) permettent de diagnostiquer les sous-types de LLA.</li></ul>

 

 

Subtypes of ALL2827.00000000000Subtypes of ALLSubtypes of ALLSEnglishOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MD000Flat ContentHealth A-Z<p>Acute lymphoblastic leukemia (ALL) can be broken down into different subtypes. Learn about the subtypes of ALL and how they are identified.</p><p>Lymphocytes are white blood cells that help the body defend against disease. There are different types of lymphocytes, which include B-lymphocytes and T-lymphocytes.</p> <p>Acute lymphoblastic leukemia (ALL) occurs when the DNA inside an immature lymphocyte (lymphoblast) changes. This mutation can happen at different developmental stages of the lymphocyte. Depending on whether the genetic change takes place in a developing B-lymphocyte or T-lymphocyte, ALL can be further broken down into different subtypes. Identifying your child’s ALL subtype will help doctors decide their treatment plan.</p><h2> Key points </h2> <ul><li>ALL can be classified as B-lymphoblastic leukemia or T-lymphoblastic leukemia, but can be further broken down into different subtypes.</li> <li>Identifying your child’s ALL subtype will help doctors plan their treatment.</li> <li>Precursor B-cell ALL is the most common subtype of ALL.</li> <li>Immunophenotyping (or flow cytometry) tests can diagnose ALL subtypes.</li></ul><h2>What are the subtypes of ALL?</h2> <p>The World Health Organization’s (WHO) 2016 revision of myeloid neoplasms and acute leukemia now classifies ALL as B-lymphoblastic leukemia or T-lymphoblastic leukemia, with further subdivisions based on molecular characteristics.</p> <ul><li>Precursor B-cell ALL occurs when DNA changes in young B-cells (B-lymphoblasts).</li> <li> T-cell ALL occurs when DNA changes in young T-cells (T-lymphoblasts). </li></ul> <h2>How common is each ALL subtype?</h2> <p>Precursor B-cell ALL is the most common subtype of ALL. It accounts for about 80-85% of childhood ALL cases. </p> <h2>How do we identify each ALL subtype?</h2> <p>Normal lymphocytes have specific proteins on their surface, called antigens. Cancerous B-cells and T-cells also have similar antigens. Diagnostic techniques can distinguish the type of antigen on the surface of leukemic cells. These tests are called immunophenotyping (or flow cytometry). </p> <h3>Precursor B-cell ALL</h3> <p>Precursor B-cell ALL is identified because of unique antigens on the surface of precursor B-lymphoblasts, such as CD10, CD19, CD79a, and HLA-DR and other B-cell associated antigens.</p> <h3>T-cell ALL</h3> <p>Immunophenotyping detects T-lymphoblasts that express surface antigens including CD7 plus CD2 or CD5, as well as a unique antigen that floats inside T-lymphoblasts called cytoplasmic CD3.</p>Subtypes of ALL

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