Acute myeloid leukemia: bone marrow transplantAAcute myeloid leukemia: bone marrow transplantAcute Myeloid Leukemia: Bone Marrow TransplantEnglishOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemNon-drug treatmentAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MD000Flat ContentHealth A-Z<p> Learn which children with acute myeloid leukemia are recommended for a bone marrow transplant (BMT).</p><p>A bone marrow transplant (BMT), also known as a stem cell transplant, is a procedure that places (transplants) healthy blood stem cells into a body where the stem cells have been destroyed by chemotherapy or radiation. It may be seen as a method to ‘rescue’ your child from the severe side effects of high dose chemotherapy and radiation. When the stem cells come from another person, the procedure is called an allogeneic BMT.</p> <p>Your child may be recommended to have a BMT, depending on whether they have high-risk or low-risk AML. The risk category of your child’s AML depends on the type of chromosome changes that occur inside leukemic cells. </p><h2> Key points </h2> <ul><li>A bone marrow transplant (BMT) transplants blood stem cells into a body where the stem cells have been destroyed by chemotherapy or radiation.</li> <li>A BMT is not usually recommended for low-risk groups of AML.</li> <li> Children with high-risk AML re recommended for a BMT.</li></ul>
LMA : Greffe de moelle osseuseLLMA : Greffe de moelle osseuseAcute Myeloid Leukemia: Bone Marrow TransplantFrenchOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemNon-drug treatmentAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MDFlat ContentHealth A-Z<p>Enfants souffrant de LMA à qui une greffe de la moelle osseuse est recommandée.</p><p>La greffe de la moelle osseuse, aussi appelée greffe de cellules souches, est une intervention où l’on greffe des cellules souches sanguines saines dans un organisme dont les cellules souches ont été détruites par la chimiothérapie ou la radiothérapie. On peut la considérer comme une méthode permettant de sauver votre enfant des effets secondaires dangereux d’une dose élevée de chimiothérapie ou de radiothérapie. Lorsque ces cellules ont été données par une autre personne, cette intervention s’appelle une allogreffe de moelle osseuse ou une greffe de moelle osseuse allogénique.</p><p>Il est possible qu’on recommande que votre enfant ait une greffe de moelle osseuse, selon le niveau de risque que comporte sa LMA. Ce niveau dépend du type de mutations chromosomiques se produisant dans ses cellules cancéreuses. </p><h2>À retenir</h2><ul><li>En pratiquant une greffe de la moelle osseuse, on greffe des cellules souches sanguines dans un organisme dont les cellules souches ont été détruites par la chimiothérapie ou la radiothérapie.</li><li>On déconseille généralement la greffe de moelle osseuse chez les groupes d’enfants souffrant de LMA à risque faible.</li><li>Par contre, on la recommande chez les enfants atteints de LMA à risque élevé.</li></ul>

 

 

Acute myeloid leukemia: bone marrow transplant2848.00000000000Acute myeloid leukemia: bone marrow transplantAcute Myeloid Leukemia: Bone Marrow TransplantAEnglishOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemNon-drug treatmentAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MD000Flat ContentHealth A-Z<p> Learn which children with acute myeloid leukemia are recommended for a bone marrow transplant (BMT).</p><p>A bone marrow transplant (BMT), also known as a stem cell transplant, is a procedure that places (transplants) healthy blood stem cells into a body where the stem cells have been destroyed by chemotherapy or radiation. It may be seen as a method to ‘rescue’ your child from the severe side effects of high dose chemotherapy and radiation. When the stem cells come from another person, the procedure is called an allogeneic BMT.</p> <p>Your child may be recommended to have a BMT, depending on whether they have high-risk or low-risk AML. The risk category of your child’s AML depends on the type of chromosome changes that occur inside leukemic cells. </p><h2> Key points </h2> <ul><li>A bone marrow transplant (BMT) transplants blood stem cells into a body where the stem cells have been destroyed by chemotherapy or radiation.</li> <li>A BMT is not usually recommended for low-risk groups of AML.</li> <li> Children with high-risk AML re recommended for a BMT.</li></ul><h2>Low-risk AML</h2><p>Unless your child has a poor response to induction therapy or relapses, BMT is not recommended for low-risk groups of AML.</p><h2>High-risk AML</h2><p>AML is categorized as high-risk based on genetic changes in the leukemia cells or poor response to induction therapy (as indicated by a positive minimal residue disease test of greater than 0.1%). In healthy cells, chromosomes exist in pairs. Each pair is numbered from 1 to 23. Some children with AML have leukemic cells that are missing one chromosome from a pair. These children are considered to have high-risk AML, and are recommended for a BMT. The high-risk groups of AML include:</p><ul><li> Monosomy 5/del (5q). This happens when one copy of chromosome 5 is missing.</li><li> Monosomy 7. This happens when one copy of chromosome 7 is missing.</li><li> Presence of FLT3/ITD mutations of greater than 0.4. </li></ul><p>For more information, please see the <a href="/Article?contentid=2477&language=English">Blood and Marrow Transplant Learning Hub</a>.</p>Acute myeloid leukemia: bone marrow transplantFalse

Thank you to our sponsors

AboutKidsHealth is proud to partner with the following sponsors as they support our mission to improve the health and wellbeing of children in Canada and around the world by making accessible health care information available via the internet.