AboutKidsHealth

 

 

Potential late effects of acute myeloid leukemia treatmentPPotential late effects of acute myeloid leukemia treatmentPotential Late Effects of Acute Myeloid Leukemia TreatmentEnglishOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MDFlat ContentHealth A-Z<p>Learn about long-term and late effects from acute myeloid leukemia (AML) treatment. </p><p>Your child takes many medicines while being treated for acute myeloid leukemia (AML). Although they do a good job of killing leukemic cells, they can affect normal cells as well. Damage to healthy cells in different parts of the body can appear as side effects many years after your child finishes treatment. </p><p>Some people develop a side effect during therapy that continues to affect them after they finish treatment. This is called a long-term effect. Alternatively, health problems may arise many years later. These are called late effects. </p><p>Many of the potential long-term effects are a consequence of certain kinds of chemotherapy. Some children also receive radiation to the brain. This is called cranial radiation therapy (CRT). CRT may put your child more at risk for some of the effects discussed in this section. </p><p>Much of our current understanding of the long-term and late effects of leukemia treatment comes from the Childhood Cancer Survivor Study (CCSS) that was launched in the early 1990s. </p><p>Fortunately, improvements to current leukemia therapies allow many survivors to live normal lives. Many childhood leukemia survivors experience minimal late or long-term effects.</p><h2> Key points </h2><ul><li>Medicines for acute myeloid leukemia (AML) can damage normal cells, which can appear as a side effect years after treatment.</li><li> The majority of children with AML will not face fertility issues.</li><li>During chemotherapy, your child may take medicines that can cause heart problems.</li></ul>
Effets tardifs potentiels des traitements pour la leucémie myéloblastique aiguëEEffets tardifs potentiels des traitements pour la leucémie myéloblastique aiguëPotential Late Effects of Acute Myeloid Leukemia TreatmentFrenchOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MDFlat ContentHealth A-Z<p>Les effets à long terme et les effets tardifs du traitement contre la leucémie myéloblastique aiguë.</p><p>Votre enfant prend plusieurs médicaments pendant son traitement contre la leucémie myéloblastique aiguë. Si ces traitements arrivent bien à tuer les cellules cancéreuses, ils peuvent toucher les cellules normales également. Les dommages faits aux cellules normales dans différentes parties du corps peuvent se manifester en effets secondaires de nombreuses années après que l’enfant a terminé ses traitements.</p><p>Chez certaines personnes, des effets secondaires qui surviennent pendant le traitement perdurent même après qu’elles l'ont terminé. C’est ce que l’on appelle un effet à long terme. Par ailleurs, des problèmes de santé peuvent aussi survenir de nombreuses années après. C’est ce que l’on appelle un effet tardif.</p><p>Nombre des effets à long terme potentiels sont une conséquence de certains types de chimiothérapie. Certains enfants reçoivent aussi des radiations au cerveau. C’est ce que l’on appelle la radiothérapie crânienne (RTC). La RTC élève le risque que votre enfant développe certains effets dont il est question dans cette section.</p><p>La majorité de nos connaissances actuelles sur les effets à long terme et les effets tardifs de la leucémie est issue de la Childhood Cancer Survivor Study (CCSS) entamée au début des années 1990.</p><p>Heureusement, des améliorations aux traitements actuels de la leucémie permettent à de nombreux survivants de vivre une vie normale. De nombreux survivants de la leucémie infantile sont aux prises avec des effets tardifs ou à long terme minimes. </p><h2>À retenir </h2><ul><li>Les médicaments contre la leucémie myéloblastique aiguë peuvent endommager les cellules saines, un effet indésirable qui peut se manifester des années après le traitement.</li><li>La majorité des enfants atteints de leucémie myéloblastique aiguë ne seront pas affectés par des problèmes de fertilité.</li><li>Au cours de la chimiothérapie, votre enfant pourrait prendre des médicaments qui peuvent causer des problèmes cardiaques.</li></ul>

 

 

Potential late effects of acute myeloid leukemia treatment3204.00000000000Potential late effects of acute myeloid leukemia treatmentPotential Late Effects of Acute Myeloid Leukemia TreatmentPEnglishOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MDFlat ContentHealth A-Z<p>Learn about long-term and late effects from acute myeloid leukemia (AML) treatment. </p><p>Your child takes many medicines while being treated for acute myeloid leukemia (AML). Although they do a good job of killing leukemic cells, they can affect normal cells as well. Damage to healthy cells in different parts of the body can appear as side effects many years after your child finishes treatment. </p><p>Some people develop a side effect during therapy that continues to affect them after they finish treatment. This is called a long-term effect. Alternatively, health problems may arise many years later. These are called late effects. </p><p>Many of the potential long-term effects are a consequence of certain kinds of chemotherapy. Some children also receive radiation to the brain. This is called cranial radiation therapy (CRT). CRT may put your child more at risk for some of the effects discussed in this section. </p><p>Much of our current understanding of the long-term and late effects of leukemia treatment comes from the Childhood Cancer Survivor Study (CCSS) that was launched in the early 1990s. </p><p>Fortunately, improvements to current leukemia therapies allow many survivors to live normal lives. Many childhood leukemia survivors experience minimal late or long-term effects.</p><h2> Key points </h2><ul><li>Medicines for acute myeloid leukemia (AML) can damage normal cells, which can appear as a side effect years after treatment.</li><li> The majority of children with AML will not face fertility issues.</li><li>During chemotherapy, your child may take medicines that can cause heart problems.</li></ul><h2>Fertility</h2><p>When your child enters adulthood, they may start to think about having children. Current treatment methods have improved to such an extent that majority of children with AML are unlikely to face issues with fertility when they are older. If your child receives a bone marrow transplant during their treatment, they may have problems with fertility when they are older.</p><p>If your child is diagnosed around the age of puberty (age 11 or 12) or later, you and your child may want to consider banking your child’s sperm. Boys who are pre-pubertal may be able to undergo an experimental procedure called a testicular biopsy. Discuss these options with your child’s doctor if you or your child have any questions or concerns. You may be referred to a fertility preservation team. </p><h2>Heart problems</h2><p>During your child’s chemotherapy, they may take medicines called daunorubicin and doxorubicin. They belong to the class of medicines called anthracyclines, which are commonly used to treat many different types of cancers. Depending on the dose, these medicines can be toxic to cells inside the heart. Damage to the heart cells can make it hard for the heart muscle to pump properly. Eventually, the heart just cannot keep up and your child can develop symptoms like fatigue or breathing problems. </p><p>If your child received anthracyclines during treatment, they should see a doctor often and have a heart ultrasound (echocardiogram) regularly. Girls treated with anthracyclines who become pregnant later need to have a regular echocardiogram done. These will be done as part of the routine follow-up. </p><h2>Secondary leukemia</h2><p>While on chemotherapy, your child takes medicines that work by damaging the DNA of leukemic cells. These drugs are called alkylating agents. One example is Busulfan, which is used before a stem cell transplant. Alongside attacking the cancerous marrow and blood cells, the alkylating agents can also damage the DNA of healthy blood cells. This can cause leukemia for a second time.</p><p>Regular check-ups after treatment are important so that your child's doctor can check for any early signs of these cancers. </p><h2>Complications related to bone marrow transplants</h2><p>As part of your child’s treatment plan, they may have also received a bone marrow transplant. There are many long-term effects associated with this procedure. </p>Potential late effects of acute myeloid leukemia treatmentFalse

Thank you to our sponsors

AboutKidsHealth is proud to partner with the following sponsors as they support our mission to improve the health and wellbeing of children in Canada and around the world by making accessible health care information available via the internet.