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ThalassemiaTThalassemiaThalassemiaEnglishHaematologyChild (0-12 years);Teen (13-18 years)BodyCardiovascular systemConditions and diseasesCaregivers Adult (19+)NA2010-05-07T04:00:00Z9.4000000000000048.6000000000000586.000000000000Health (A-Z) - ConditionsHealth A-Z<p>An overview of the causes, symptoms and treatment of this blood disorder caused by a defect in the gene that controls the production of hemoglobin.</p><h2>What is thalassemia?</h2> <p>Thalassemia is a group of blood diseases caused by production of abnormal hemoglobin. Hemoglobin is a protein found in red blood cells that carries oxygen to the body. Thalassemia is an inherited form of <a href="/Article?contentid=841&language=English">anemia</a>. It most commonly affects children of Mediterranean, African and Asian descent. There are many different forms of thalassemia and the degree of severity ranges from no symptoms at all to fatal disease. If you have thalassemia minor (trait), you are a carrier of the disease and your red blood cells are smaller than normal, but you are healthy. Thalassemia major can be fatal. People with alpha thalassemia major die in infancy. People with beta thalassemia major require regular blood transfusions. There are other forms of thalassemia which are not as severe.</p><h2>Key points</h2> <ul> <li>Thalassemia is a blood disorder caused by a defect in the gene that controls the production of hemoglobin.</li> <li>It is an inherited form of anemia that most commonly affects children of Mediterranean, African and Asian descent.</li> <li>Children with thalassemia major may look pale and have shortness of breath.</li> <li>Thalassemia major is treated by monthly blood transfusions.</li> </ul><h2>Signs and symptoms of thalassemia</h2><p>Children with thalassemia major may show signs and symptoms in early infancy. The symptoms are similar to children with anemia:</p><ul><li>pale skin</li><li>fatigue</li><li>weakness</li><li>shortness of breath</li></ul><p>Other symptoms may include:</p><ul><li>irritability</li><li>yellow discolouration of skin (jaundice)</li><li>slow growth</li><li>protruding abdomen</li><li>facial bone deformities</li><li>dark urine</li></ul><h2>Causes</h2><p>The blood disorder is caused by a defect in the gene that controls the production of hemoglobin. The defective gene causes an inability to produce normal hemoglobin. Children inherit this gene from one or both parents. If a child inherits the faulty gene from both parents, the child will have thalassemia major. If the faulty gene is only passed on by one parent, the child has thalassemia minor. The child then becomes a carrier of the defective gene.</p> <figure class="asset-c-100"> <span class="asset-image-title">Beta thalassemia heredity</span> <img src="https://assets.aboutkidshealth.ca/akhassets/Beta_thal_MED_ILL_EN.jpg" alt="Chromosome distribution chart for a male and a female both carrying the beta thalassemia gene in one chromosome" /> <figcaption class="asset-image-caption">In this example, both parents are carriers of beta thalassemia. They may have mild anemia. Their children may inherit one, two, or no copies of the beta thalassemia gene. If a baby inherits one copy of the gene, she will have thalassemia trait like her parents. If a baby inherits two copies, she will have beta thalassemia (moderate to severe anemia).</figcaption> </figure><h2>What a doctor can do to help your child with thalassemia</h2> <p>Your child's doctor will take into consideration the signs and symptoms you have observed. A diagnosis can only be confirmed by blood tests. Thalassemia minor does not require treatment. Thalassemia major is treated by monthly blood transfusions. Recurrent blood transfusions cause an overload of iron in your child's body. This can lead to heart or liver damage. Such damage can be prevented by medicine to remove the excess iron. </p><h2>Complications</h2> <p>A child with this blood disorder may have gallstones. Other children may have poor growth. Heart failure and infection are the leading causes of death among children when the disorder is left untreated. With treatment, the major complications are related to iron overload.</p><h2>When to seek medical assistance</h2> <p>If your child shows symptoms of anemia, visit your child's doctor as soon as possible. If you have a family history of thalassemia, you should be tested to see if you are a carrier.</p>
الثلاسيميااالثلاسيمياThalassemiaArabicHaematologyChild (0-12 years);Teen (13-18 years)BodyCardiovascular systemConditions and diseasesCaregivers Adult (19+)NA2010-05-07T04:00:00Z7.0000000000000065.0000000000000519.000000000000Flat ContentHealth A-Z<p>نظرة عامة سهلة الفهم عن الاسباب والاعراض وعلاج اضطراب الدم هذا الناجم عن خلل في الجينة التي تتحكم في إنتاج الهيموغلوبين.</p>
地中海贫血地中海贫血ThalassemiaChineseSimplifiedHaematologyChild (0-12 years);Teen (13-18 years)BodyCardiovascular systemConditions and diseasesCaregivers Adult (19+)NA2010-05-07T04:00:00Z65.00000000000007.00000000000000519.000000000000Flat ContentHealth A-Z由控制血红蛋白的基因异常导致的血液异常:病因、症状及治疗的普及性概述。<br>
地中海貧血地中海貧血ThalassemiaChineseTraditionalHaematologyChild (0-12 years);Teen (13-18 years)BodyCardiovascular systemConditions and diseasesCaregivers Adult (19+)NA2010-05-07T04:00:00Z65.00000000000007.00000000000000519.000000000000Flat ContentHealth A-Z由控制血紅蛋白的基因异常導致的血液异常:病因、症狀及治療的普及性概述。
ThalassémieTThalassémieThalassemiaFrenchHaematologyChild (0-12 years);Teen (13-18 years)BodyCardiovascular systemConditions and diseasesCaregivers Adult (19+)NA2010-05-07T04:00:00Z10.000000000000048.0000000000000560.000000000000Health (A-Z) - ConditionsHealth A-Z<p> Voici un aperçu facile à comprendre des causes, des symptômes et du traitement de ce trouble du sang causé par un défaut dans les gènes qui contrôlent la production d’hémoglobine.</p><h2>Qu’est-ce que la thalassémie?</h2> <p>La thalassémie est un groupe de maladies du sang causées par une production d’hémoglobine anormale. L'hémoglobine est une protéine que l'on trouve dans les globules rouges qui font circuler l’oxygène dans l’organisme. La thalassémie est une forme héréditaire d’anémie. Elle touche le plus souvent les enfants d’origine méditerranéenne, africaine et asiatique. La thalassémie prend différentes formes, et le degré de gravité passe d'aucun symptôme à une maladie mortelle. Si vous avez une thalassémie mineure (trait), vous êtes porteur de la maladie et vos globules rouges sont plus petits que la normale, mais vous êtes tout de même en santé. Par contre, une thalassémie majeure peut être fatale. Les personnes atteintes de thalassémie alpha meurent en bas âge. Les personnes atteintes de thalassémie majeure bêta ont besoin de transfusions sanguines régulières. Il existe d’autres formes de thalassémie qui sont moins graves.</p><h2>À retenir</h2> <ul><li>La thalassémie est une maladie du sang causée par un défaut dans le gène qui contrôle la production d’hémoglobine.</li><li>La maladie est une forme d'anémie héréditaire qui touche le plus souvent les enfants d’origine méditerranéenne, africaine et asiatique.</li><li>Les enfants atteints de thalassémie majeure peuvent avoir l’air pâle et avoir le souffle court.</li><li>La thalassémie majeure est traitée par des transfusions sanguines mensuelles.</li></ul><h2>Signes et symptômes de la thalassémie</h2> <p>Les enfants atteints de thalassémie majeure peuvent afficher les signes et symptômes dans la petite enfance. Les symptômes sont semblables à ceux que provoque l’anémie chez les enfants :</p> <ul> <li>peau pâle;</li> <li>fatigue;</li> <li>faiblesse;</li> <li>souffle court.</li> </ul> <p>Voici d’autres symptômes :</p> <ul> <li>irritabilité;</li> <li>peau de couleur jaune (jaunisse);</li> <li>croissance lente;</li> <li>protrusion de l’abdomen;</li> <li>déformations de l’os facial;</li> <li>urine foncée.</li> </ul><h2>Causes</h2><p>Cette maladie du sang est causée par un défaut dans le gène qui contrôle la production d’hémoglobine. Le gène défectif cause une incapacité de produire de l’hémoglobine normale. Les enfants héritent de ce gène d’un parent ou des deux parents. Si un enfant hérite du gène défectueux des deux parents, l’enfant aura une thalassémie majeure, et si le gène défectueux est transmis par un seul des deux parents, l’enfant aura une thalassémie mineure. L’enfant devient également porteur du gène défectueux. </p> <figure class="asset-c-100"> <span class="asset-image-title">Hériter de la bêta-thalassémie</span><img src="https://assets.aboutkidshealth.ca/akhassets/Beta_thal_MED_ILL_FR.jpg" alt="La distribution des chromosomes d’un homme et d’une femme, chacun avec un chromosome avec un gène de bêta-thalassémie" /><figcaption class="asset-image-caption">Dans cet exemple, les deux parents sont porteurs de la bêta-thalassémie. Ils pourraient souffrir d'une légère anémie. Leurs enfants pourraient hériter d'une, deux ou d'aucune copie du gène responsable de la bêta-thalassémie. Si un bébé hérite d'une copie du gène, il aura le caractère bêta-thalassémique comme ses parents. Si un bébé hérite de deux copies, il souffrira de bêta-thalassémie (anémie modérée à grave).</figcaption> </figure><h2>Ce qu'un médecin peut faire pour aider votre enfant atteint de thalassémie</h2> <p>Le médecin de votre enfant tiendra compte des signes et des symptômes que vous aurez observés. Le diagnostic ne peut être confirmé que par des analyses sanguines. La thalassémie mineure ne requiert aucun traitement. La thalassémie majeure est traitée par des transfusions sanguines mensuelles. Les transfusions sanguines récurrentes peuvent causer une surcharge de fer dans l'organisme de votre enfant, ce qui peut entraîner des dommages au coeur ou au foie. La prise de médicaments qui éliminent le fer excédentaire peut empêcher ces dommages. </p><h2>Complications</h2> <p>Un enfant atteint de cette maladie du sang pourrait avoir des pierres au foie. D’autres enfants peuvent avoir des troubles de croissance. L’insuffisance cardiaque et l'infection sont les principales causes de décès chez les enfants si la maladie n'est pas traitée. Grâce au traitement, les complications majeures se limitent à une surcharge de fer.</p><h2>Quand consulter</h2> <p>Si votre enfant affiche des symptômes d’anémie, visitez le médecin de votre enfant aussi tôt que possible. Si vous avez des antécédents familiaux de thalassémie, vous devriez passer un test de dépistage pour voir si vous êtes porteur.</p>
TalasemiaTTalasemiaThalassemiaSpanishNAChild (0-12 years);Teen (13-18 years)NANANAAdult (19+)NA2010-05-07T04:00:00Z65.00000000000007.00000000000000519.000000000000Flat ContentHealth A-Z<p>Una descripción sencilla de las causas, los síntomas y el tratamiento de este trastorno de la sangre causado por un defecto en el gen que controla la producción de hemoglobina.</p>
இரத்த அழிவுச் சோகை (தலசீமியா)இரத்த அழிவுச் சோகை (தலசீமியா)ThalassemiaTamilNAChild (0-12 years);Teen (13-18 years)NANANAAdult (19+)NA2010-05-07T04:00:00Z65.00000000000007.00000000000000519.000000000000Flat ContentHealth A-Z<p>ஹிமோகுளோபின் உற்பத்தி செய்வதைக் கட்டுப்படுத்தும் மரபணுவிலுள்ள குறைபாட்டினால் உருவாகும் இந்த இரத்த வியாதிக்கான காரணங்கள், அறிகுறிகள், மற்றும் சிகிச்சை பற்றி இலகுவாக விளங்கிக் கொள்ளக்கூடிய ஒரு கண்ணோட்டம். </p>
تھیلیسیمیا‮ ‬یا‮ ‬خون‮ ‬میں‮ ‬خرابی‮ ‬کی‮ ‬بیماریتتھیلیسیمیا‮ ‬یا‮ ‬خون‮ ‬میں‮ ‬خرابی‮ ‬کی‮ ‬بیماریThalassemiaUrduNAChild (0-12 years);Teen (13-18 years)NANANAAdult (19+)NA2010-05-07T04:00:00Z65.00000000000007.00000000000000519.000000000000Flat ContentHealth A-Zآسانی سے سمجھ میں آنے والا جائزہ جس میں خون کی خرابی یا بے ترتیبی کی وجوھات ، علامات اور علاج کے بارے میں بتاتا ھے جسکی وجہ جننیات کی خرابی ھوتی ھے،جو خون میں ھیموگلوبین کی پیداوار کو کنٹرول کرتی ھیں۔

 

 

 

 

Thalassemia840.000000000000ThalassemiaThalassemiaTEnglishHaematologyChild (0-12 years);Teen (13-18 years)BodyCardiovascular systemConditions and diseasesCaregivers Adult (19+)NA2010-05-07T04:00:00Z9.4000000000000048.6000000000000586.000000000000Health (A-Z) - ConditionsHealth A-Z<p>An overview of the causes, symptoms and treatment of this blood disorder caused by a defect in the gene that controls the production of hemoglobin.</p><h2>What is thalassemia?</h2> <p>Thalassemia is a group of blood diseases caused by production of abnormal hemoglobin. Hemoglobin is a protein found in red blood cells that carries oxygen to the body. Thalassemia is an inherited form of <a href="/Article?contentid=841&language=English">anemia</a>. It most commonly affects children of Mediterranean, African and Asian descent. There are many different forms of thalassemia and the degree of severity ranges from no symptoms at all to fatal disease. If you have thalassemia minor (trait), you are a carrier of the disease and your red blood cells are smaller than normal, but you are healthy. Thalassemia major can be fatal. People with alpha thalassemia major die in infancy. People with beta thalassemia major require regular blood transfusions. There are other forms of thalassemia which are not as severe.</p><h2>Key points</h2> <ul> <li>Thalassemia is a blood disorder caused by a defect in the gene that controls the production of hemoglobin.</li> <li>It is an inherited form of anemia that most commonly affects children of Mediterranean, African and Asian descent.</li> <li>Children with thalassemia major may look pale and have shortness of breath.</li> <li>Thalassemia major is treated by monthly blood transfusions.</li> </ul><h2>Signs and symptoms of thalassemia</h2><p>Children with thalassemia major may show signs and symptoms in early infancy. The symptoms are similar to children with anemia:</p><ul><li>pale skin</li><li>fatigue</li><li>weakness</li><li>shortness of breath</li></ul><p>Other symptoms may include:</p><ul><li>irritability</li><li>yellow discolouration of skin (jaundice)</li><li>slow growth</li><li>protruding abdomen</li><li>facial bone deformities</li><li>dark urine</li></ul><h2>Causes</h2><p>The blood disorder is caused by a defect in the gene that controls the production of hemoglobin. The defective gene causes an inability to produce normal hemoglobin. Children inherit this gene from one or both parents. If a child inherits the faulty gene from both parents, the child will have thalassemia major. If the faulty gene is only passed on by one parent, the child has thalassemia minor. The child then becomes a carrier of the defective gene.</p> <figure class="asset-c-100"> <span class="asset-image-title">Beta thalassemia heredity</span> <img src="https://assets.aboutkidshealth.ca/akhassets/Beta_thal_MED_ILL_EN.jpg" alt="Chromosome distribution chart for a male and a female both carrying the beta thalassemia gene in one chromosome" /> <figcaption class="asset-image-caption">In this example, both parents are carriers of beta thalassemia. They may have mild anemia. Their children may inherit one, two, or no copies of the beta thalassemia gene. If a baby inherits one copy of the gene, she will have thalassemia trait like her parents. If a baby inherits two copies, she will have beta thalassemia (moderate to severe anemia).</figcaption> </figure><h2>What a doctor can do to help your child with thalassemia</h2> <p>Your child's doctor will take into consideration the signs and symptoms you have observed. A diagnosis can only be confirmed by blood tests. Thalassemia minor does not require treatment. Thalassemia major is treated by monthly blood transfusions. Recurrent blood transfusions cause an overload of iron in your child's body. This can lead to heart or liver damage. Such damage can be prevented by medicine to remove the excess iron. </p><h2>Complications</h2> <p>A child with this blood disorder may have gallstones. Other children may have poor growth. Heart failure and infection are the leading causes of death among children when the disorder is left untreated. With treatment, the major complications are related to iron overload.</p><h2>Prevention</h2> <p>People with any form of thalassemia should get genetic counseling. Prenatal tests are also available.</p><h2>When to seek medical assistance</h2> <p>If your child shows symptoms of anemia, visit your child's doctor as soon as possible. If you have a family history of thalassemia, you should be tested to see if you are a carrier.</p>https://assets.aboutkidshealth.ca/akhassets/Beta_thal_MED_ILL_EN.jpgThalassemiaFalse

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