G6PD deficiencyGG6PD deficiencyG6PD deficiencyEnglishGeneticsChild (0-12 years);Teen (13-18 years)NACardiovascular systemConditions and diseasesCaregivers Adult (19+)NA2009-11-06T05:00:00ZMelanie Kirby-Allen, MD, FRCPC8.0000000000000062.0000000000000865.000000000000Health (A-Z) - ConditionsHealth A-Z<p>G6PD deficiency can cause haemolysis and anaemia. Learn what this has to do with blood, the problems it can cause and what medicines you should avoid.</p><h2>What is G6PD deficiency?</h2> <p>Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that helps red blood cells to work properly. Some people have less than the usual amount of G6PD in their red blood cells. This is called G6PD deficiency, or favism. </p> <p>Most people with G6PD deficiency have completely normal health, but sometimes it can cause problems. This guide explains the problems G6PD deficiency may cause and what to do if your child has problems. </p><h2>Key points</h2> <ul> <li>G6PD is an enzyme that helps protect red blood cells. </li> <li>Most people who have G6PD deficiency are healthy, but sometimes fever or certain medicines and foods can break down their red blood cells (haemolysis) and cause anaemia. </li> <li>Your child with G6PD deficiency should avoid certain medicines and foods.</li> <li>Tell your pharmacist, nurse and doctor that your child has G6PD deficiency.</li> <li>If your child has symptoms of anaemia, call your family doctor or take your child to the nearest Emergency Department. </li> </ul><h2>G6PD deficiency is passed on from parents to children</h2> <p>G6PD deficiency is an inherited disorder, which means it is passed from one or both parents to the child. It affects males more often than females.</p> <p>About 400 million people worldwide have G6PD deficiency. Anyone can have G6PD deficiency, but it is most common in people whose families came from Africa or other areas where malaria has been common, such as the Mediterranean, Caribbean and South-East Asia. G6PD deficiency is usually milder in people of African origin and more severe in people of Mediterranean and Asian origin.</p><h2>Your child should not take certain medicines</h2> <p>If your child has G6PD deficiency, they should not take any of the following medicines:</p> <ul> <li><a href="/Article?contentid=77&language=English">acetylsalicylic acid (ASA)</a></li> <li>ascorbic acid (Vitamin C) </li> <li>chloramphenicol </li> <li>chloroquine </li> <li><a href="/Article?contentid=119&language=English">dapsone</a> </li> <li>dimercaprol </li> <li><a href="/Article?contentid=120&language=English">doxorubicin</a> </li> <li>mepacrine </li> <li>methylene blue </li> <li>methyldopa</li> <li>nalidixic acid </li> <li>naphthalene </li> <li><a href="/Article?contentid=201&language=English">nitrofurantoin</a> </li> <li>phenazopyridine </li> <li><a href="/Article?contentid=222&language=English">primaquine</a> </li> <li>quinine </li> <li>sulfacetamide </li> <li>sulfadiazine </li> <li>sulfamethoxazole (Co-trimoxazole, Septra) </li> <li>sulfanilamide </li> <li>sulfapyridine </li> <li><a href="/Article?contentid=243&language=English">sulfisoxazole</a> (Pediazole) </li> <li>toluidine blue </li> </ul> <p>This list only contains the names of drugs that are more likely to cause haemolysis in patients with G6PD deficiency. The list may change at a later time. Sometimes medicines that are not on this list can also cause problems. Tell your pharmacist, nurse and doctor that your child has G6PD deficiency and ask them to check before giving your child any medicine, including herbal remedies. </p> <p>If your child's doctor feels that your child needs to take one of the medicines on the list, your child will have their blood tested while taking the medicine. </p> <p>The risk and severity of haemolysis is almost always dose-related. This means that if your child takes a higher dose of one of these medicines, they are more likely to develop haemolysis and it is more likely to be severe. </p> <h2>Your child should avoid mothballs and certain foods</h2> <p>Your child should not come in close contact with mothballs (naphthalene).</p> <p>Your child should not eat fava beans. Some people should also avoid red wine, all beans, blueberries, soya products, tonic water and camphor. </p><h2>G6PD deficiency can cause problems</h2> <h3>Problems for newborn babies</h3> <p>If a mother carries G6PD deficiency, she may pass it on to one or more of her children. Some babies may get jaundiced (yellow) shortly after they are born. This is more likely for baby boys. </p> <p>Severe jaundice can be serious for newborn babies if it is not treated. It is usually treated by putting the baby under a special light for a few days. </p> <p>Many babies with G6PD deficiency are diagnosed because they have jaundice soon after birth. Once the jaundice has passed, they should not get other problems from G6PD deficiency, as long as they avoid fava beans and certain medicines. </p> <h3>Problems for children and adults</h3> <p>Most people with G6PD deficiency have completely normal health, but sometimes it can cause problems.</p> <p>Some children and adults with G6PD deficiency may develop haemolysis and <a href="/Article?contentid=841&language=English">anaemia</a> after they are exposed to any of these triggers:</p> <ul> <li>if they get a fever </li> <li>if they take certain medicines listed later in this guide </li> <li>if they eat fava beans; this is called favism </li> </ul> <p>If your child is exposed to a trigger that causes haemolysis, sometimes there are no symptoms at all. In more serious cases, your child may have one or more of the following symptoms of <a href="/Article?contentid=841&language=English">anaemia</a>: </p> <ul> <li>pale skin </li> <li>fatigue </li> <li>rapid heartbeat </li> <li>rapid breathing </li> <li>shortness of breath </li> <li>jaundice (yellowing of the skin and eyes) </li> <li>backache </li> <li>dark, tea-coloured urine </li> </ul> <p>If your child is experiencing any of these symptoms, call your family doctor or go to the nearest Emergency Department.</p> <p>Once the trigger is removed or resolved, the symptoms of G6PD deficiency usually go away fairly quickly, usually within a few weeks. </p>
Déficit en G-6-PDDDéficit en G-6-PDG6PD deficiencyFrenchGeneticsChild (0-12 years);Teen (13-18 years)NACardiovascular systemConditions and diseasesCaregivers Adult (19+)NA2009-11-06T05:00:00ZMelanie Kirby-Allen, MD, FRCPC8.0000000000000062.0000000000000865.000000000000Health (A-Z) - ConditionsHealth A-Z<p> Apprenez comment ce déficit est relié au sang, les problèmes qu’il peut entraîner et les médicaments à éviter.</p><h2>Qu'est-ce qu'un déficit en G-6-PD?</h2> <p>Le glucose-6-phosphate déshydrogénase (G-6-PD) est une enzyme qui aide au fonctionnement des globules rouges. Certaines personnes ont moins de G-6-PD que la normale dans leurs globules rouges. On appelle cela un déficit en G-6-PD ou favisme.</p> <p>La plupart des personnes avec un déficit en G-6-PD ont une santé normale, mais parfois, ce déficit peut poser des problèmes. Le présent texte décrit les problèmes qu'un déficit en G-6-PD peut causer. Il indique également que faire si votre enfant a des problèmes.</p><h2>À retenir</h2> <ul> <li>Le G-6-PD est une enzyme qui aide à protéger les globules rouges.</li> <li>La plupart des personnes atteintes d'un déficit en G-6-PD sont en bonne santé, mais parfois de la fièvre ou certains médicaments ou aliments peuvent entraîner la destruction de leurs globules rouges (hémolyse) et une anémie.</li> <li>Votre enfant atteint de déficit en G-6-PD devrait éviter certains médicaments et certains aliments.</li> <li>Dites à votre pharmacien, à l'infirmièer et au médecin que votre enfant a un déficit en G-6-PD.</li> <li>Si votre enfant a des symptômes d'anémie, communiquez avec votre médecin de famille ou amenez-le au service d'urgence le plus proche. </li> </ul><h2>Le déficit en G-6-PD est transmis des parents aux enfants</h2> <p>Le déficit en G-6-PD est un problème congénital (héréditaire), ce qui signifie qu'il est transmis d'un parent ou des deux parents à l'enfant. Ce déficit touche plus souvent les garçons que les filles.</p> <p>Environ 400 millions de personnes dans le monde ont un déficit en G-6-PD. Tout le monde peut avoir un déficit en G 6-PD, mais c'est plus courant chez les personnes dont les familles sont originaires d'Afrique ou d'autres régions où le paludisme (malaria) est courant, comme la Méditerranée, les Antilles et l'Asie du Sud-Est. Le déficit en G-6-PD est habituellement plus atténué chez les personnes d'origine africaine, et plus aiguë chez les personnes d'origine méditerranéenne et asiatique.</p><h2>Votre enfant ne devrait pas prendre certains médicaments</h2> <p>Si votre enfant a un déficit en G-6-PD, il ne devrait pas prendre les médicaments suivants :</p> <ul> <li>acide acétylsalicylique (AAS ou aspirine) </li> <li>acide ascorbique (vitamine C) </li> <li>chloramphénicol </li> <li>chloroquine </li> <li>dapsone </li> <li>dimercaprol </li> <li>doxorubicine </li> <li>mépacrine </li> <li>bleu de méthylène </li> <li>méthyldopa </li> <li>acide nalidixique </li> <li>naphtaline </li> <li>nitrofurantoïne </li> <li>phénazopyridine </li> <li>primaquine </li> <li>quinine </li> <li>sulfacétamide </li> <li>sulfadiazine </li> <li>sulfaméthoxazole (Co-trimoxazole, Septra) </li> <li>sulfamide </li> <li>sulfapyridine </li> <li>acétylsulfisoxazole (Pediazole) </li> <li>bleu de toluidine </li> </ul> <p>Cette liste comprend uniquement les noms des médicaments les plus susceptibles de causer une hémolyse chez les patients atteints de déficit en G-6-PD. La liste pourrait changer ultérieurement. Parfois des médicaments qui ne sont pas sur cette liste peuvent aussi poser des problèmes. Dites à votre pharmacien, à l'infirmiere et à votre médecin que votre enfant a un déficit en G-6-PD et demandez-leur de vérifier avant de donner un médicament à votre enfant, y compris des médicaments à base de plantes. </p> <p>Si le médecin de votre enfant pense qu'il doit prendre un des médicaments sur la liste, votre enfant aura des prises de sang pendant qu'il sera sous traitement.</p> <p>Le risque et la gravité d'une hémolyse sont pratiquement toujours liés au dosage. Cela signifie que si votre enfant prend une dose plus importante d'un de ces médicaments, il aura plus de risque de développer une hémolyse et elle risque d'être sévère.</p> <h2>Votre enfant devrait éviter les boules à mites et certains aliments</h2> <p>Votre enfant ne devrait pas entrer en contact avec des boules à mites (naphtaline).</p> <p>Votre enfant ne devrait pas manger de gourganes (fèves fava). Certaines personnes évitent toute consommation de vin rouge, toutes les légumineuses, les bleuets, les produits à base de soya, l'eau gazéifiée et le camphre.</p><h2>Le déficit en G-6-PD peut entraîner des problèmes</h2> <h3>Problèmes chez les nouveau-nés</h3> <p>Si une mère est porteuse du déficit en G-6-PD, elle peut le transmettre à un ou plusieurs de ses enfants. Certains bébés peuvent avoir une jaunisse peu de temps après leur naissance. C'est plus fréquent chez les garçons.</p> <p>Une jaunisse sérieuse peut être grave chez les nouveau-nés si elle n'est pas traitée. La jaunisse est habituellement traitée en plaçant le bébé sous une lumière spéciale pour quelques jours.</p> <p>De nombreux bébés avec un déficit en G-6-PD sont diagnostiqués parce qu'ils ont une jaunisse peu de temps après leur naissance. Une fois la jaunisse passée, ils ne devraient pas avoir d'autres problèmes liés au déficit en G-6-PD, tant qu'ils évitent la consommation de gourganes (fèves fana, cultivées au Québec) et certains médicaments. </p> <h3>Problèmes chez les enfants et les adultes</h3> <p>La plupart des gens avec un déficit en G-6-PD ont une santé parfaitement normale, mais parfois, ce déficit peut causer certains problèmes.</p> <p>Certains enfants et certains adultes avec un déficit en G-6-PD peuvent développer une hémolyse et une anémie après une exposition à un de ces déclencheurs :</p> <ul> <li>s'ils ont de la fièvre,</li> <li>s'ils prennent certains médicaments indiqués ci-après,</li> <li>s'ils consomment des gourganes; on appelle cela du favisme. </li> </ul> <p>Si votre enfant est exposé à un déclencheur qui cause l'hémolyse, il n'y a parfois aucun symptôme. Dans les cas plus graves, votre enfant peut montrer un des symptômes d'anémie suivants : </p> <ul> <li>teint pâle;</li> <li>fatigue;</li> <li>rythme cardiaque rapide;</li> <li>respiration rapide;</li> <li>souffle court;</li> <li>jaunisse (peau et yeux jaunes);</li> <li>maux de dos;</li> <li>urine de couleur foncée comme du thé.</li> </ul> <p>Si votre enfant a certains de ces symptômes, communiquez avec votre médecin de famille ou rendez-vous au service d'urgence le plus proche.</p> <p>Une fois le déclencheur supprimé ou réglé, les symptômes de déficit en G-6-PD s'estompent généralement assez rapidement, habituellement en quelques semaines. </p>

 

 

G6PD deficiency870.000000000000G6PD deficiencyG6PD deficiencyGEnglishGeneticsChild (0-12 years);Teen (13-18 years)NACardiovascular systemConditions and diseasesCaregivers Adult (19+)NA2009-11-06T05:00:00ZMelanie Kirby-Allen, MD, FRCPC8.0000000000000062.0000000000000865.000000000000Health (A-Z) - ConditionsHealth A-Z<p>G6PD deficiency can cause haemolysis and anaemia. Learn what this has to do with blood, the problems it can cause and what medicines you should avoid.</p><h2>What is G6PD deficiency?</h2> <p>Glucose-6-phosphate dehydrogenase (G6PD) is an enzyme that helps red blood cells to work properly. Some people have less than the usual amount of G6PD in their red blood cells. This is called G6PD deficiency, or favism. </p> <p>Most people with G6PD deficiency have completely normal health, but sometimes it can cause problems. This guide explains the problems G6PD deficiency may cause and what to do if your child has problems. </p><h2>G6PD protects red blood cells</h2> <p>Red blood cells carry oxygen to all parts of the body. G6PD is an enzyme that helps the red blood cells to function normally. It also helps protect them against substances that can build up when you have a fever or take certain medicines. </p> <p>If a person does not have enough G6PD, some of their red blood cells may be destroyed when they have a fever or when they take certain medicines. The breakdown of red blood cells is called haemolysis (say: he-MOLL-iss-iss). If this happens, the person may not have enough red blood cells and may become anaemic. </p><h2>Key points</h2> <ul> <li>G6PD is an enzyme that helps protect red blood cells. </li> <li>Most people who have G6PD deficiency are healthy, but sometimes fever or certain medicines and foods can break down their red blood cells (haemolysis) and cause anaemia. </li> <li>Your child with G6PD deficiency should avoid certain medicines and foods.</li> <li>Tell your pharmacist, nurse and doctor that your child has G6PD deficiency.</li> <li>If your child has symptoms of anaemia, call your family doctor or take your child to the nearest Emergency Department. </li> </ul><h2>G6PD deficiency is passed on from parents to children</h2> <p>G6PD deficiency is an inherited disorder, which means it is passed from one or both parents to the child. It affects males more often than females.</p> <p>About 400 million people worldwide have G6PD deficiency. Anyone can have G6PD deficiency, but it is most common in people whose families came from Africa or other areas where malaria has been common, such as the Mediterranean, Caribbean and South-East Asia. G6PD deficiency is usually milder in people of African origin and more severe in people of Mediterranean and Asian origin.</p><h2>Your child should not take certain medicines</h2> <p>If your child has G6PD deficiency, they should not take any of the following medicines:</p> <ul> <li><a href="/Article?contentid=77&language=English">acetylsalicylic acid (ASA)</a></li> <li>ascorbic acid (Vitamin C) </li> <li>chloramphenicol </li> <li>chloroquine </li> <li><a href="/Article?contentid=119&language=English">dapsone</a> </li> <li>dimercaprol </li> <li><a href="/Article?contentid=120&language=English">doxorubicin</a> </li> <li>mepacrine </li> <li>methylene blue </li> <li>methyldopa</li> <li>nalidixic acid </li> <li>naphthalene </li> <li><a href="/Article?contentid=201&language=English">nitrofurantoin</a> </li> <li>phenazopyridine </li> <li><a href="/Article?contentid=222&language=English">primaquine</a> </li> <li>quinine </li> <li>sulfacetamide </li> <li>sulfadiazine </li> <li>sulfamethoxazole (Co-trimoxazole, Septra) </li> <li>sulfanilamide </li> <li>sulfapyridine </li> <li><a href="/Article?contentid=243&language=English">sulfisoxazole</a> (Pediazole) </li> <li>toluidine blue </li> </ul> <p>This list only contains the names of drugs that are more likely to cause haemolysis in patients with G6PD deficiency. The list may change at a later time. Sometimes medicines that are not on this list can also cause problems. Tell your pharmacist, nurse and doctor that your child has G6PD deficiency and ask them to check before giving your child any medicine, including herbal remedies. </p> <p>If your child's doctor feels that your child needs to take one of the medicines on the list, your child will have their blood tested while taking the medicine. </p> <p>The risk and severity of haemolysis is almost always dose-related. This means that if your child takes a higher dose of one of these medicines, they are more likely to develop haemolysis and it is more likely to be severe. </p> <h2>Your child should avoid mothballs and certain foods</h2> <p>Your child should not come in close contact with mothballs (naphthalene).</p> <p>Your child should not eat fava beans. Some people should also avoid red wine, all beans, blueberries, soya products, tonic water and camphor. </p><h2>G6PD deficiency can cause problems</h2> <h3>Problems for newborn babies</h3> <p>If a mother carries G6PD deficiency, she may pass it on to one or more of her children. Some babies may get jaundiced (yellow) shortly after they are born. This is more likely for baby boys. </p> <p>Severe jaundice can be serious for newborn babies if it is not treated. It is usually treated by putting the baby under a special light for a few days. </p> <p>Many babies with G6PD deficiency are diagnosed because they have jaundice soon after birth. Once the jaundice has passed, they should not get other problems from G6PD deficiency, as long as they avoid fava beans and certain medicines. </p> <h3>Problems for children and adults</h3> <p>Most people with G6PD deficiency have completely normal health, but sometimes it can cause problems.</p> <p>Some children and adults with G6PD deficiency may develop haemolysis and <a href="/Article?contentid=841&language=English">anaemia</a> after they are exposed to any of these triggers:</p> <ul> <li>if they get a fever </li> <li>if they take certain medicines listed later in this guide </li> <li>if they eat fava beans; this is called favism </li> </ul> <p>If your child is exposed to a trigger that causes haemolysis, sometimes there are no symptoms at all. In more serious cases, your child may have one or more of the following symptoms of <a href="/Article?contentid=841&language=English">anaemia</a>: </p> <ul> <li>pale skin </li> <li>fatigue </li> <li>rapid heartbeat </li> <li>rapid breathing </li> <li>shortness of breath </li> <li>jaundice (yellowing of the skin and eyes) </li> <li>backache </li> <li>dark, tea-coloured urine </li> </ul> <p>If your child is experiencing any of these symptoms, call your family doctor or go to the nearest Emergency Department.</p> <p>Once the trigger is removed or resolved, the symptoms of G6PD deficiency usually go away fairly quickly, usually within a few weeks. </p>G6PD deficiency

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