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Inflammation and the immune systemIInflammation and the immune systemInflammation and the immune systemEnglishImmunologyChild (0-12 years);Teen (13-18 years)BodyImmune systemConditions and diseasesCaregivers Adult (19+)NA2013-05-13T04:00:00ZSusanne Benseler, MD;Manisha Sickand, MSc;Marinka Twilt, MD10.000000000000049.0000000000000613.000000000000Health (A-Z) - ConditionsHealth A-Z<p>Inflammation is the body's protective response against infection. Learn about the signs and symptoms of inflammation and how your body fights it.</p><h2>What is inflammation?</h2><p>Inflammation is the body's normal response to injuries or infections. You may often hear the words infection and inflammation together, but they mean very different things. Infection refers to the invasion and multiplication of a pathogen within the body, while inflammation is the body's protective response against infection. Inflammation is a complex process involving various types of immune cells, clotting proteins and signaling molecules, all of which change over time.</p> <figure class="asset-c-100"><span class="asset-image-title"> Inflammation</span><img src="https://assets.aboutkidshealth.ca/akhassets/IMD_inflammation_EN.jpg" alt="Splinter in the skin causing pain, warmth, redness and swelling" /><figcaption class="asset-image-caption"> Inflammation is the normal response of your body’s immune system to injuries and harmful things that enter your body. Immune cells quickly react to the damaged area to fix the problem. During the process, you may feel symptoms like pain, warmth, swelling and redness.</figcaption> </figure><h2>Key points</h2><ul><li> Inflammation is the body's normal response to injuries or infections. Cells of the immune system travel to the site of injury or infection and cause inflammation.</li> <li>The four signs of inflammation include warmth, redness, swelling and pain.</li><li>Long-term inflammatory conditions include asthma, colitis and Crohn's disease, arthritis, vasculitis and nephritis.</li><li>Different types of cells involved in our immune system include lymphocytes, antibodies and proteins secreted from B cells, neutrophils, monocytes, eosinophils and basophils.</li></ul><h2>Signs of inflammation</h2> <p>The cells of our immune system immediately travel to the site of injury or irritation and cause inflammation. This includes a widening of local blood vessels that result in an outflow of fluid and immune cells into surrounding tissues. This process often causes temporary discomfort, resulting in what physicians refer to as the four cardinal signs of inflammation:<br></p> <ul> <li>warmth </li> <li>redness </li> <li>swelling </li> <li>pain.<br></li> </ul> <p>Normally, inflammation disappears on its own after the irritation has been removed and the body is adequately protected. In some conditions, however, inflammation is the disease; it starts in the absence of harmful irritations and continues with no resolution. This leads to organ function problems. Examples of long-term inflammatory conditions include: </p> <ul> <li>Inflammatory airway disease: <a href="https://akhpub.aboutkidshealth.ca/article?contentid=1470&language=English">Asthma</a></li> <li><a href="https://akhpub.aboutkidshealth.ca/article?contentid=821&language=English">Inflammatory bowel disease</a>: <a href="https://akhpub.aboutkidshealth.ca/article?contentid=924&language=English">Colitis</a> and <a href="https://akhpub.aboutkidshealth.ca/article?contentid=923&language=English">Crohn's disease</a></li> <li>Inflammatory joint disease: <a href="/article?contentid=1049&language=English">Arthritis</a><br></li> <li>Inflammatory blood vessel disease: <a href="https://akhpub.aboutkidshealth.ca/article?contentid=914&language=English">Vasculitis</a> </li> <li>Inflammatory kidney disease: Nephritis </li> </ul>
L’inflammation et le système immunitaireLL’inflammation et le système immunitaireInflammation and the immune systemFrenchImmunologyChild (0-12 years);Teen (13-18 years)BodyImmune systemConditions and diseasesCaregivers Adult (19+)NA2013-05-13T04:00:00ZSusanne Benseler, MD;Manisha Sickand, MSc;Marinka Twilt, MD10.000000000000049.0000000000000613.000000000000Health (A-Z) - ConditionsHealth A-Z<p>L’inflammation est la réponse du corps à l’infection. Apprenez à reconnaître les signes et les symptômes d’inflammation et comment votre corps y réagit.</p><h2>L’inflammation, qu’est-ce que c’est?</h2><p>L’inflammation est la réaction normale de l’organisme aux blessures et aux infections. Les mots « infection » et « inflammation » sont souvent employés ensemble, mais leur sens est très différent. L’infection est l’invasion de l’organisme par un agent pathogène qui s’y multiplie, tandis que l’inflammation est la réponse de l’organisme pour se protéger de l’infection. L’inflammation est un processus complexe qui fait intervenir plusieurs types de cellules immunitaires, des protéines de coagulation et des molécules de signalisation qui, toutes, évoluent avec le temps.</p> <figure class="asset-c-100"> <span class="asset-image-title">Inflammation</span><img src="https://assets.aboutkidshealth.ca/akhassets/IMD_inflammation_FR.jpg" alt="Une esquille dans la peau causant de douleur, chaleur, rougeur et gonflement" /><figcaption class="asset-image-caption">L’inflammation est la réponse normale du système immunitaire de l’organisme aux lésions et aux éléments nuisibles qui entrent dans le corps. Les cellules immunitaires réagissent rapidement dans la zone atteinte pour régler le problème. Au cours du processus, on peut ressentir des symptômes tels que douleur, chaleur, gonflement et rougeur.</figcaption> </figure><h2>À retenir<br></h2><ul><li>L’inflammation est la réponse normale du corps aux lésions et aux infections. Des cellules du système immunitaire se déplacent vers le site de la lésion ou de l’infection et causent une inflammation.</li><li>Les quatre principaux signes d’inflammation sont la chaleur, la rougeur, l’enflure et la douleur.</li><li>Les maladies inflammatoires à long terme comprennent l’asthme, la colite, la maladie de Crohn, l’arthrite, la vasculite et la néphrite.</li><li>Parmi les différents types de cellules de notre système immunitaire, il y a les lymphocytes, les anticorps et les protéines des cellules B, les neutrophiles, les monocytes, les éosinophiles et les basophiles.</li></ul><p>Les cellules du système immunitaire se rendent immédiatement à l’endroit de la blessure ou de l’irritation et provoquent une inflammation. Cette réaction inclut un élargissement des vaisseaux sanguins à proximité, qui entraîn​e un écoulement de liquide et de cellules immunitaires dans les tissus environnants. Ce processus entraîne souvent une gêne temporaire et aboutit à ce que les médecins appellent les quatre signes cardinaux de l’inflammation :</p><ul><li>chaleur</li><li>rougeur</li><li>gonflement</li><li> <a href="https://akhpub.aboutkidshealth.ca/article?contentid=1652&language=French">douleur</a><br></li></ul><p>Normalement, l’inflammation disparaît d’elle-même une fois que l’irritation est apaisée et que l’organisme est adéquatement protégé. Dans certains cas, cependant, l’inflammation est la maladie; elle apparaît en l’absence d’irritations nuisibles et se poursuit indéfiniment. Cela entraîne des problèmes de fonction des organes. Exemples d’affections inflammatoires à long terme : </p><ul><li>Maladie inflammatoire des voies aériennes : <a href="https://akhpub.aboutkidshealth.ca/article?contentid=785&language=French">asthme</a></li><li> <a href="https://akhpub.aboutkidshealth.ca/article?contentid=821&language=French">Maladie intestinale inflammatoire</a> : <a href="https://akhpub.aboutkidshealth.ca/article?contentid=924&language=French">colite</a> et <a href="https://akhpub.aboutkidshealth.ca/article?contentid=923&language=French">maladie de Crohn</a></li><li>Maladie inflammatoire des articulations :<a href="/Article?contentid=1049&language=French"> arthrite</a></li><li>Maladie inflammatoire des vaisseaux sanguins : <a href="https://akhpub.aboutkidshealth.ca/article?contentid=914&language=french">vasculite</a><br></li><li>Maladie inflammatoire des reins : néphrite </li></ul>

 

 

Inflammation and the immune system926.000000000000Inflammation and the immune systemInflammation and the immune systemIEnglishImmunologyChild (0-12 years);Teen (13-18 years)BodyImmune systemConditions and diseasesCaregivers Adult (19+)NA2013-05-13T04:00:00ZSusanne Benseler, MD;Manisha Sickand, MSc;Marinka Twilt, MD10.000000000000049.0000000000000613.000000000000Health (A-Z) - ConditionsHealth A-Z<p>Inflammation is the body's protective response against infection. Learn about the signs and symptoms of inflammation and how your body fights it.</p><h2>What is inflammation?</h2><p>Inflammation is the body's normal response to injuries or infections. You may often hear the words infection and inflammation together, but they mean very different things. Infection refers to the invasion and multiplication of a pathogen within the body, while inflammation is the body's protective response against infection. Inflammation is a complex process involving various types of immune cells, clotting proteins and signaling molecules, all of which change over time.</p> <figure class="asset-c-100"><span class="asset-image-title"> Inflammation</span><img src="https://assets.aboutkidshealth.ca/akhassets/IMD_inflammation_EN.jpg" alt="Splinter in the skin causing pain, warmth, redness and swelling" /><figcaption class="asset-image-caption"> Inflammation is the normal response of your body’s immune system to injuries and harmful things that enter your body. Immune cells quickly react to the damaged area to fix the problem. During the process, you may feel symptoms like pain, warmth, swelling and redness.</figcaption> </figure><h2>Key points</h2><ul><li> Inflammation is the body's normal response to injuries or infections. Cells of the immune system travel to the site of injury or infection and cause inflammation.</li> <li>The four signs of inflammation include warmth, redness, swelling and pain.</li><li>Long-term inflammatory conditions include asthma, colitis and Crohn's disease, arthritis, vasculitis and nephritis.</li><li>Different types of cells involved in our immune system include lymphocytes, antibodies and proteins secreted from B cells, neutrophils, monocytes, eosinophils and basophils.</li></ul><h2>Signs of inflammation</h2> <p>The cells of our immune system immediately travel to the site of injury or irritation and cause inflammation. This includes a widening of local blood vessels that result in an outflow of fluid and immune cells into surrounding tissues. This process often causes temporary discomfort, resulting in what physicians refer to as the four cardinal signs of inflammation:<br></p> <ul> <li>warmth </li> <li>redness </li> <li>swelling </li> <li>pain.<br></li> </ul> <p>Normally, inflammation disappears on its own after the irritation has been removed and the body is adequately protected. In some conditions, however, inflammation is the disease; it starts in the absence of harmful irritations and continues with no resolution. This leads to organ function problems. Examples of long-term inflammatory conditions include: </p> <ul> <li>Inflammatory airway disease: <a href="https://akhpub.aboutkidshealth.ca/article?contentid=1470&language=English">Asthma</a></li> <li><a href="https://akhpub.aboutkidshealth.ca/article?contentid=821&language=English">Inflammatory bowel disease</a>: <a href="https://akhpub.aboutkidshealth.ca/article?contentid=924&language=English">Colitis</a> and <a href="https://akhpub.aboutkidshealth.ca/article?contentid=923&language=English">Crohn's disease</a></li> <li>Inflammatory joint disease: <a href="/article?contentid=1049&language=English">Arthritis</a><br></li> <li>Inflammatory blood vessel disease: <a href="https://akhpub.aboutkidshealth.ca/article?contentid=914&language=English">Vasculitis</a> </li> <li>Inflammatory kidney disease: Nephritis </li> </ul><h2>Tools of our immune system</h2> <figure> <span class="asset-image-title">Types of white blood cells</span> <img src="https://assets.aboutkidshealth.ca/akhassets/IMD_cells_immune_EN.jpg" alt="Lymphocyte, monocyte, neutrophil, basophil and eosinophil in bone marrow" /> <figcaption class="asset-image-caption">All white blood cells are produced in the bone marrow. These cells help to fight infection in your body.</figcaption> </figure> <ul><li>White blood cells, also known as leukocytes, are the cells of the immune system. White blood cells help fight infection by attacking invaders and consuming infected or dead cells. The body has various types of white blood cells, but all are produced in the bone marrow (the soft middle part of our bones). </li><li>Lymphocytes are a special type of white blood cell. There are two major classes of lymphocytes: T cells and B cells. B cells make up about 5% to 15% of the lymphocytes in our bodies. B cells develop in the bone marrow and are responsible for producing antibodies. There are thousands of different B cells in our body, each of which produces a unique antibody. T cells develop in the thymus and help coordinate a rapid and tailored immune response to specific infectious organisms. </li><li>Antibodies are proteins that are secreted from B cells. Antibodies help the immune system recognize foreign proteins that do not belong to the body. In doing so, they initiate an inflammatory response and clear the body of the invader.</li><li>Neutrophils are the white blood cells that arrive first at the site of injury. They release chemical signals that attract other immune cells in an effort to help protect the body.</li><li>Monocytes are special white blood cells that mature into cells called macrophages. Macrophages respond to signals released from neutrophils, and they are capable of eating and destroying potential pathogenic invaders in a process called phagocytosis.</li><li>Eosinophils and basophils are less ubiquitous white blood cells that have roles in parasite infections.<br><br></li></ul>https://assets.aboutkidshealth.ca/akhassets/IMD_inflammation_EN.jpgInflammation and the immune systemFalse

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