Subtypes of AMLSSubtypes of AMLSubtypes of AMLEnglishOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MD8.2000000000000058.1000000000000521.000000000000Flat ContentHealth A-Z<p> Learn about the different subtypes of acute myeloid leukemia (AML) and how they are diagnosed.</p><p>There are 8 different subtypes of acute myeloid leukemia (AML). When your child is diagnosed with AML, doctors do a bone marrow aspirate test to determine the subtype.</p><h2> Key points </h2> <ul><li> AML occurs when a change in the DNA of the stem cell stops it from developing normally.</li> <li> Abnormalities in chromosomes can cause AML.</li> <li> AML is classified based on genetic changes in leukemia cells.</li> <li> Your child's AML subtype helps doctors understand how to treat the disease.</li> <li> Most subtypes of AML follow similar treatment protocols.</li></ul>
Sous-types de leucémie myéloblastique aiguëSSous-types de leucémie myéloblastique aiguëSubtypes of AMLFrenchOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MDFlat ContentHealth A-Z<p>Récouvrez les différents sous-types de leucémie myéloblastique aiguë (LMA) et comment ils sont diagnostiqués.</p><p>Il existe huit différents sous-types de leucémie myéloblastique aiguë (LMA). Quand une LMA est diagnostiquée chez votre enfant, les médecins font une ponction de sa moelle osseuse pour déterminer le sous-type de LMA.</p><h2>À retenir</h2><ul><li>La LMA se produit lorsqu’un changement dans l’ADN de la cellule souche l’empêche de se développer normalement.</li><li>Les anomalies des chromosomes peuvent causer la LMA.</li><li>La LMA est classifiée en fonction des changements génétiques dans les cellules leucémiques.</li><li>Le sous-type de LMA de votre enfant aide les médecins à comprendre comment traiter la maladie.</li><li>La plupart des sous-types de LMA suivent des protocoles de traitement similaires.</li></ul>

 

 

 

 

Subtypes of AML2831.00000000000Subtypes of AMLSubtypes of AMLSEnglishOncologyChild (0-12 years);Teen (13-18 years)BodySkeletal systemConditions and diseasesAdult (19+)NA2018-03-06T05:00:00ZOussama Abla, MDDanielle Weidman, MDKarin Landenberg, MD8.2000000000000058.1000000000000521.000000000000Flat ContentHealth A-Z<p> Learn about the different subtypes of acute myeloid leukemia (AML) and how they are diagnosed.</p><p>There are 8 different subtypes of acute myeloid leukemia (AML). When your child is diagnosed with AML, doctors do a bone marrow aspirate test to determine the subtype.</p><h2> Key points </h2> <ul><li> AML occurs when a change in the DNA of the stem cell stops it from developing normally.</li> <li> Abnormalities in chromosomes can cause AML.</li> <li> AML is classified based on genetic changes in leukemia cells.</li> <li> Your child's AML subtype helps doctors understand how to treat the disease.</li> <li> Most subtypes of AML follow similar treatment protocols.</li></ul><h2>How your child's AML subtype is determined</h2><p>After taking a sample of your child’s marrow, lab specialists look at two different biological features: the type of blood cell involved, and the chromosomes.</p><h3>The type of blood cell that has become cancerous</h3><p>AML occurs when the DNA inside a young blood cell (myeloid cell) in the bone marrow changes so that it cannot develop into a mature blood cell. Cancerous myeloid cells are also called "leukemic myeloblasts." </p><p>Normally, myeloid cells develop into different type of blood cells. These include:</p><ul><li>monocytes, which develop further into white blood cells called macrophages. These cells help our body fight infection.</li><li>erythrocytes (red cells)</li><li> platelets</li></ul><p>AML can occur in any one of these cell types.<br></p> <figure><span class="asset-image-title">Blood cell development</span> <img src="https://assets.aboutkidshealth.ca/akhassets/Blood_cell_development_MED_ILL_EN.jpg" alt="Illustration of blood cell development from primitive stem cell" /> <figcaption class="asset-image-caption">All blood cells develop from one type of cell, called a primitive stem cell. Stem cells are found primarily in the bone marrow, but also in circulating blood and in a baby’s umbilical cord. In AML and ALL, there is a change in the DNA of the stem cell that stops it from developing normally.</figcaption> </figure> <h3>Abnormal chromosomes </h3><p>Chromosomes are long lengths of DNA inside cells. In a healthy cell, there are normally 46 copies of chromosomes. There are two copies of each chromosome. Each pair is numbered 1 through to 23. </p> <figure><span class="asset-image-title">Chromosomal translocation</span><img src="http://assets.aboutkidshealth.ca/akhassets/Chromosomal_translocation_MED_ILL_EN.jpg" alt="Normal chromosomes and chromosomes with translocation" /> </figure><figure> <span class="asset-image-title">Chromosomal inversion</span><img src="http://assets.aboutkidshealth.ca/akhassets/Chromosomal_inversion_MED_ILL_EN.jpg" alt="Normal chromosome and chromosome with inversion" /> </figure> <p>Abnormalities in chromosomes can cause AML. These abnormalities include:</p><ul><li> Chromosome translocation, which happens when a part of a chromosome separates itself and sticks onto another, unrelated chromosome. </li><li> Chromosome inversion, which happens when part of a chromosome turns upside down.</li></ul><p>Both processes produce new chromosomes that express genes in different ways, and can lead to AML.</p><h2>What are the AML subtypes?</h2><p>The older French American British (FAB) classification system subdivided AML according to the type of cell that becomes cancerous. This system classified AML into 8 different subtypes, ranging from AML M0 to M7. </p><p>The World Health Organization (WHO) updated its classifications of AML in 2016 based on genetic changes in the leukemia cells, including:</p><ul><li>AML with recurrent genetic abnormalities</li><li>AML with myelodysplasia-related features </li><li> Therapy-related myeloid neoplasms</li><li> AML, not otherwise specified</li><li>Myeloid sarcoma</li><li>Myeloid proliferations related to Down syndrome:</li><ul><li>Transient abnormal myelopoiesis (TAM)</li><li>Myeloid leukemia associated with Down syndrome.</li></ul><li>Blastic plasmacytoid dendritic cell neoplasm (BPDCN). </li></ul><h2>Why is it important to know your child’s AML subtype?</h2><p>Your child’s AML subtype helps doctors understand how best to treat the disease. It also predicts the likely prognosis of your child’s leukemia. </p><p>All the subtypes of AML follow similar treatment protocols, except subtype M3 or APL.</p> <br>Subtypes of AMLFalse