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Inflammation and auto-inflammation

Inflammation is the body's protective response against infections and injuries. Auto-inflammation occurs when the body produces an inflammatory response against its own healthy tissues. Learn about the signs and symptoms of inflammation and auto-inflammation.

What causes juvenile idiopathic arthritis (JIA)?

This page describes how joint inflammation happens and how juvenile idiopathic arthritis can hurt your joints. It also outlines some of the symptoms of arthritis in young people.

Juvenile enthesitis-related arthritis: Treatment

Juvenile Enthesitis Related Arthritis is treated with medicines that reduce inflammation of the joints. Learn about the specific drugs used to treat ERA.

Optic neuritis

Optic neuritis is inflammation of the optic nerve in the eye. It can occur in one eye or both eyes at the same time. Learn about the signs and symptoms of optic neuritis and what to expect.

Macrophage activation syndrome (MAS)

Macrophage activation syndrome (MAS) occurs when the immune system is overactivated and causes inflammation. Learn about the signs, causes and treatment of MAS.

What causes juvenile idiopathic arthritis (JIA)?

Find out why arthritis can occur in young people. This page describes how joint inflammation happens, and how juvenile idiopathic arthritis can hurt your joints. It also outlines some of the symptoms of arthritis in young people.

Neuroinflammatory disorders

Neuroinflammatory disorders are conditions in which inflammation affects the central nervous system (the brain, spinal cord, and/or optic nerves).

Antibody-mediated inflammatory disorders

Antibody-mediated neuroinflammatory disorders are conditions where the body’s immune system attacks its own cells in the central nervous system (the brain, spinal cord, and/or optic nerves). Learn about the different types of antibody-mediated neuroinflammatory brain disorders and what the signs and symptoms are for each.

Autoimmune hepatitis

Does your child have autoimmune hepatitis? Learn the facts and how you can help.

Juvenile enthesitis-related arthritis (ERA)

Juvenile enthesitis-related arthritis includes swelling and pain where tendons and ligaments attach to bone. It affects more boys than girls.

Oral immune therapy for your hospitalized baby

Learn about the benefits of providing oral immune therapy to your hospitalized baby using expressed breast milk.

Ulcerative colitis

​​Information for parents and children with the inflammatory bowel disease, ulcerative colitis.

Transient synovitis

Learn about transient synovitis in children, or temporary inflammation of the lining of a joint.

Lupus (systemic lupus erythematosus)

Learn about systemic lupus erythematosus (SLE), including diagnosis, treatment and management of lupus.

Post-infectious glomerulonephritis

In children, post-infectious glomerulonephritis is usually caused by inflammation that follows an infection. Learn more about diagnosis and treatment.

Chronic recurrent multifocal osteomyelitis (CRMO)

Information about an inflammatory disease called chronic recurrent multifocal osteomyelitis which causes pain and swelling in the bones.

Multisystem inflammatory syndrome in children (MIS-C)

Learn about multisystem inflammatory syndrome in children (MIS-C), a rare syndrome linked to a SARS-CoV-2 infection.

Systemic juvenile idiopathic arthritis (sJIA)

Systemic juvenile idiopathic arthritis (sJIA) is an autoinflammatory disease that causes swelling in the joints. Discover quick facts about sJIA, including its symptoms.

Biologic agents and JIA

Crohn's disease

Information for parents and children with the inflammatory bowel disease, Crohn's disease.

What is juvenile idiopathic arthritis (JIA)?

JIA can occur in young people, up to age 16. Discover the differences in arthritis between young people and adults, how common arthritis is in young people, and how it can affect the joints.

Bone marrow and the immune system

Parents can learn about bone marrow and the immune system, as they prepare for their child's blood and marrow transplant (BMT)/cellular therapy (CT).

Eosinophilic esophagitis (EoE)

Information for children, adolescents and their families about eosinophilic esophagitis (EoE), a disorder that involves inflammation and swelling of the esophagus.

Immunizations for children and teens with suppressed immune systems

Treatment to suppress the immune system affects how your child’s body responds to routine immunizations. This guide discusses how to keep your child healthy while taking immune-suppressing treatment.